Pontine stimulation overcomes developmental limitations in the neural mechanisms of eyeblink conditioning
Pontine stimulation overcomes developmental limitations in the neural mechanisms of eyeblink conditioning
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DOI：
10.1101/lm.91105
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发表时间：
2005-05-01
影响因子：
2
通讯作者：
Campolattaro, MM
中科院分区：
文献类型：
--
作者：
Freeman, JH;Rabinak, CA;Campolattaro, MM
大鼠出生后 (P) P17 和 P24 天内听觉刺激期间的脑桥神经元激活在个体发育上增加。脑桥神经元是眨眼调节的条件刺激 (CS) 通路的重要组成部分，为小脑提供苔藓纤维输入。在这里，我们检查了 P17 大鼠脑桥对 CS 反应的发育限制是否可以通过直接刺激 CS 途径来克服。使用脑桥刺激作为 CS，在 P17-P18 和 P24-P25 的婴儿大鼠中建立眨眼条件反射。条件反射的速率或水平不存在与年龄相关的显着差异。在两个年龄组中，通过刺激 CS 建立的眨眼条件反应被同侧小脑核和上层皮质的失活所消除。研究结果表明，CS 通路的发育变化在眨眼条件反射的个体发育中发挥着重要作用。
Pontine neuronal activation during auditory stimuli increases ontogenetically between postnatal days (P) P17 and P24 in rats. Pontine neurons are an essential component of the conditioned stimulus (CS) pathway for eyeblink conditioning, providing mossy fiber input to the cerebellum. Here we examined whether the developmental limitation in pontine responsiveness to a CS in P17 rats could be overcome by direct stimulation of the CS pathway. Eyeblink conditioning was established in infant rats on P17-P18 and P24-P25 using pontine stimulation as a CS. There were no significant age-related differences in the rate or level of conditioning. Eyeblink conditioned responses established with the stimulation CS were abolished by inactivation of the ipsilateral cerebellar nuclei and overlying cortex in both age groups. The findings suggest that developmental changes in the CS pathway play an important role in the ontogeny of eyeblink conditioning.