Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine.
Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine.
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衰老过程中的精神损害：患者的选择、评估方法和乙酰左旋肉碱的治疗可能性。
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
D. Cucinotta
中科院分区：
文献类型：
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作者：
Mario Passeri;M. Iannuccelli;G. Ciotti;Bonati Pa;G. Nolfe;D. Cucinotta
作者在两个随机均质组中进行了一项双盲研究，每组15名患者，年龄超过65岁，患有轻度精神障碍。一组患者接受乙酰-L-肉毒碱治疗，2克/天，为期三个月，而另一组患者接受安慰剂治疗。使用非参数方法（Friedman-Nemenyi双向Anova和Mann Whitney U检验）对结果进行统计学评价。然而，在治疗结束时，两组在任何一项测试中均无显著差异。可以肯定的是，乙酰-L-肉毒碱治疗的患者在行为表现上显示出统计学显著的改善，（幸福痴呆量表p <0.02; Stuard医院老年病评定量表p <0.01），在记忆测试中（Rey短期p小于0.02; Rey长期p小于0.05; Corsi p小于0.05），注意力测试（Barrage测试p小于0.01）和言语流畅性测试p小于0.01）。
The authors carried out a double-blind study in two randomized homogeneous groups of both sexes of 15 patients each, over 65 years of age and suffering from mild mental impairment. One group of patients underwent therapy with acetyl-L-carnitine, 2 g/day for three months, while the other group was treated with a placebo. The statistical evaluation of the results were carried out using nonparametric methods (Friedman-Nemenyi two-way Anova and Mann Whitney U-Test). However, the two groups did not differ significantly in either test at the end of treatment. It is possible to affirm that the acetyl-L-carnitine treated patients showed statistically significant improvement in the behavioural performances (Blessed Dementia Scale p less than 0.02; Stuard Hospital Geriatric Rating Scale p less than 0.01), in the memory tests (Rey short-term p less than 0.02; Rey long-term p less than 0.05; Corsi p less than 0.05), in the attention test (Barrage test p less than 0.01) and in the Verbal Fluency test p less than 0.01).