Discontinuation of Neuroleptic Medication in Older, Outpatient Schizophrenics: A Placebo-Controlled, Double-Blind Trial
Discontinuation of Neuroleptic Medication in Older, Outpatient Schizophrenics: A Placebo-Controlled, Double-Blind Trial
复制标题
老年门诊精神分裂症患者停止服用抗精神病药物：一项安慰剂对照双盲试验
DOI：
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发表时间：
1991
影响因子：
1.9
通讯作者：
G. Nyman
中科院分区：
文献类型：
--
作者：
P. Ruskin;G. Nyman
Thirty-five schizophrenic outpatients over the age of 52 who had been stable on neuroleptic medication were all switched to haloperidol. Ten patients were unable to tolerate the haloperidol and two dropped out of the study. The remaining 23 patients were randomly and blindly assigned to haloperidol or placebo and then followed for 6 months. Five patients did not complete the study due to medical or administrative reasons. Among the patients who completed the study, five of 10 randomized to placebo relapsed compared with only one of eight randomized to haloperidol. However, three of 10 patients randomized to placebo have remained stable without medication for 2.5 years.
