Is Genetic Testing Indicated in a Pediatric Patient with Unilateral Hearing Loss or Single-Sided Deafness?
Is Genetic Testing Indicated in a Pediatric Patient with Unilateral Hearing Loss or Single-Sided Deafness?
复制标题
对于单侧听力损失或单侧耳聋的儿科患者是否需要进行基因检测？
DOI：
10.1002/lary.30715
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Hansen,MarlanR
中科院分区：
文献类型：
--
作者：
Kocharyan,Armine;Schaefer,AmandaM;Smith,RichardJH;Hansen,MarlanR
背景小儿单侧听力损失（UHL），定义为一只耳朵听力损失，而对侧耳朵听力正常，严重程度从轻度到重度不等，重度 UHL 称为单侧耳聋（SSD）。单侧听力损失可以是先天性的，也可以是后天性的。在美国，该病的发病率估计为 1000 名活产婴儿中的 0.6-0.7 例，其中学龄儿童的发病率不断增加 (2.5%-6%)（疾病控制中心早期听力检测和干预 [CDC] 数据库）。
BACKGROUNDPediatric unilateral hearing loss (UHL), defined as hearing loss in one ear and normal hearing in the contralateral ear, can range in severity from mild to profound, with profound UHL referred to as single-sided deafness (SSD). Unilateral hearing loss can be congenital or acquired. It occurs at an estimated incidence of 0.6–0.7 in 1000 live births in the United States with increasing incidence (2.5%–6%) in school-age children (Centers for Disease Control Early Hearing Detection and Intervention [CDC] Database).