Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart.
Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart.
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DOI：
10.1016/j.jacbts.2017.02.005
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Randolph GJ
中科院分区：
文献类型：
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作者：
Huang LH;Lavine KJ;Randolph GJ
淋巴血管系统在调节组织流体稳态、脂质转运和全身免疫监视方面起着关键作用。虽然人们已经认识到心脏依赖淋巴管来维持液体平衡，并且必须严格维持这种平衡以允许正常的心输出量，但直到最近才发现淋巴管系统可以作为促进心肌缺血和梗死后最佳愈合的治疗靶点。本文回顾了心脏淋巴管的主题，并强调了研究表明，使用血管内皮生长因子- c治疗靶向淋巴管的发育或运输可能是未来缺血性损伤临床应用的一个有希望的途径。
The lymphatic vasculature plays a key role in regulating tissue fluid homeostasis, lipid transport, and immune surveillance throughout the body. Although it has been appreciated that the heart relies on lymphatic vessels to maintain fluid balance and that such balance must be tightly maintained to allow for normal cardiac output, it has only recently come to light that the lymphatic vasculature may serve as a therapeutic target with which to promote optimal healing following myocardial ischemia and infarction. This article reviews the subject of cardiac lymphatic vessels and highlights studies that imply targeting of lymphatic vessel development or transport using vascular endothelial growth factor-C therapy may serve as a promising avenue for future clinical application in the context of ischemic injury.