Intrinsic actions of benzodiazepine antagonists
Intrinsic actions of benzodiazepine antagonists
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苯二氮卓类拮抗剂的内在作用
DOI：
10.1016/0304-3940(82)90268-3
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发表时间：
1982
影响因子：
2.5
通讯作者：
D. Nutt
中科院分区：
文献类型：
--
作者：
S. File;R. Lister;D. Nutt
RO 15-1788(4-20 mg/kg)单独或与氯氮卓酮(5 mg/kg)合用均可增加探索性头部浸入高于对照水平的孔板。苯二氮卓类拮抗剂的这种内在作用不能被氯氮卓酮逆转，甚至被增强。RO 15-1788单独对小鼠的运动活动无影响，但可拮抗氯氮卓酮的镇静作用。β-CCE(1 mg/kg和2 mg/kg)对小鼠的运动活动无影响，但较高剂量可减少小鼠的低头反应。
RO 15–1788 (4–20 mg/kg), both alone and in combination with chlordiazepoxide (5 mg/kg), increased exploratory head-dipping in a holeboard above control levels. This intrinsic action of a benzodiazepine antagonist is not reversed, and is even augmented, by chlordiazepoxide. RO 15–1788 alone had no effect on locomotor activity, but antagonized the sedative effects of chlordiazepoxide. β-CCE (1 and 2 mg/kg) was without effect on locomotor activity, but the higher dose reduced head-dipping.