Demonstration of human papillomavirus capsid antigen in carcinoma in situ of the larynx.

Demonstration of human papillomavirus capsid antigen in carcinoma in situ of the larynx.
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喉原位癌中人乳头瘤病毒衣壳抗原的演示。

DOI:
10.1177/000348948609500613
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发表时间:
1986
期刊:
The Annals of otology, rhinology, and laryngology
影响因子:
--
通讯作者:
Loury,M
Loury,M
中科院分区:
--
文献类型:
--
作者:
Kashima,H;Mounts,P;Kuhajda,F;Loury,M

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相似文献

我们进行了一项回顾性研究,探讨人乳头瘤病毒(HPV)在喉原位癌(CIS)的发展中的作用。从20例有喉CIS病史的患者中收集60例石蜡包埋组织标本,检查HPV衣壳抗原的存在。除4人外,其余均为男性,诊断时的平均年龄为64岁。免疫过氧化物酶技术显示,20例标本14例含有可检测的HPV衣壳抗原。对HPV感染的组织病理学特征进行的独立评估确定了14名患者和另外2名患者的病毒变化。根据声带病变的组织学严重程度确定的临床病程与HPV的存在之间没有相关性。这些结果表明,HPV应被认为是一种病因剂在喉CIS的发展。
We have undertaken a retrospective study to investigate the role of human papillomavirus (HPV) in the development of laryngeal carcinoma in situ (CIS). Sixty paraffin-embedded tissue specimens, collected from 20 patients with a history of laryngeal CIS, were examined for the presence of HPV capsid antigen. All but four individuals were men, with an average age at diagnosis of 64 years. An immunoperoxidase technique showed that 20 specimens from 14 patients contained detectable HPV capsid antigen. An independent evaluation for histopathologic features characteristic of HPV infection identified viral changes in the 14 patients as well as an additional two. No correlation was found between clinical course, as determined by histologic severity of vocal cord lesions, and presence of HPV. These results suggest that HPV should be considered an etiologic agent in the development of laryngeal CIS.
海葵毒素与体外突触神经末梢钠通道门控系统相关受体位点的结合。
DOI: 10.1073/pnas.77.3.1646
发表时间: 1980
影响因子: 11.1
作者:
J. Vincent;M. Balerna;J. Barhanin;M. Fosset;M. Lazdunski
通讯作者: M. Lazdunski
DOI: 10.1038/321774a0
发表时间: 1986-06-19
期刊: NATURE
影响因子: 64.8
作者:
HUGANIR, RL;DELCOUR, AH;HESS, GP
通讯作者: HESS, GP
箭毒毒素 A 20-α-苯甲酸盐与突触神经末梢颗粒中钠通道相关的受体位点的结合。
DOI: --
发表时间: 1981
期刊: The Journal of biological chemistry
影响因子: --
作者:
Catterall,WA;Morrow,CS;Daly,JW;Brown,GB
通讯作者: Brown,GB
DOI: 10.1073/pnas.78.7.4620
发表时间: 1981-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子: --
作者:
HARTSHORNE, RP;CATTERALL, WA
通讯作者: CATTERALL, WA
DOI: --
发表时间: 1980
影响因子: 4.2
作者:
M. Lazdunski;M. Balerna;J. Barhanin;R. Chicheportiche;M. Fosset;C. Frelin;Y. Jacques;A. Lombet;G. Ponzio;J. Pouysségur;J. Renaud;G. Romey;H. Schweitz;J. Vincent
通讯作者: J. Vincent