Demonstration of human papillomavirus capsid antigen in carcinoma in situ of the larynx.
Demonstration of human papillomavirus capsid antigen in carcinoma in situ of the larynx.
复制标题
喉原位癌中人乳头瘤病毒衣壳抗原的演示。
DOI:
10.1177/000348948609500613
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发表时间:
1986
期刊:
影响因子:
--
通讯作者:
Loury,M
中科院分区:
文献类型:
--
作者:
Kashima,H;Mounts,P;Kuhajda,F;Loury,M
We have undertaken a retrospective study to investigate the role of human papillomavirus (HPV) in the development of laryngeal carcinoma in situ (CIS). Sixty paraffin-embedded tissue specimens, collected from 20 patients with a history of laryngeal CIS, were examined for the presence of HPV capsid antigen. All but four individuals were men, with an average age at diagnosis of 64 years. An immunoperoxidase technique showed that 20 specimens from 14 patients contained detectable HPV capsid antigen. An independent evaluation for histopathologic features characteristic of HPV infection identified viral changes in the 14 patients as well as an additional two. No correlation was found between clinical course, as determined by histologic severity of vocal cord lesions, and presence of HPV. These results suggest that HPV should be considered an etiologic agent in the development of laryngeal CIS.
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DOI:
10.1073/pnas.77.3.1646
发表时间:
1980
影响因子:
11.1
作者:
J. Vincent;M. Balerna;J. Barhanin;M. Fosset;M. Lazdunski
通讯作者:
M. Lazdunski
影响因子:
64.8
作者:
HUGANIR, RL;DELCOUR, AH;HESS, GP
通讯作者:
HESS, GP
DOI:
--
发表时间:
1981
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Catterall,WA;Morrow,CS;Daly,JW;Brown,GB
通讯作者:
Brown,GB
DOI:
10.1073/pnas.78.7.4620
发表时间:
1981-01-01
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子:
--
作者:
HARTSHORNE, RP;CATTERALL, WA
通讯作者:
CATTERALL, WA
影响因子:
4.2
作者:
M. Lazdunski;M. Balerna;J. Barhanin;R. Chicheportiche;M. Fosset;C. Frelin;Y. Jacques;A. Lombet;G. Ponzio;J. Pouysségur;J. Renaud;G. Romey;H. Schweitz;J. Vincent
通讯作者:
J. Vincent