Melanoma: differences between Asian and Caucasian patients.
Melanoma: differences between Asian and Caucasian patients.
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DOI：
10.47102/annals-acadmedsg.v41n1p17
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发表时间：
2012-01
期刊：
影响因子：
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通讯作者：
H. Lee;W. Chay;M. Tang;M. Chio;S. Tan
中科院分区：
文献类型：
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作者：
H. Lee;W. Chay;M. Tang;M. Chio;S. Tan
皮肤黑色素瘤在亚洲是罕见的，黑色素瘤的临床表现和结果在东南亚没有很好的描述。此外，还不清楚各种族群体之间是否存在种族差异。我们研究的目的是介绍新加坡黑色素瘤的临床特征，并强调生活在新加坡的亚洲人和高加索人之间的种族差异。材料与方法回顾性收集了48名组织学确诊为黑色素瘤的患者的数据，这些患者均在新加坡国家皮肤中心和国家癌症中心就诊。结果肢端雀斑样痣性黑色素瘤（ALM）是新加坡最常见的黑色素瘤亚型（50%）。与ALM相比，黑素瘤的非ALM亚型在第1阶段被诊断出的比例更高（48%对25%）。ALM的诊断延迟为27个月，而其他亚型为12个月。与白人相比，亚洲患者有年龄更大、ALM比例更高和诊断延迟时间更长的趋势。结论黑色素瘤的临床表现存在地理和种族差异。需要特别调整方案，以提高对亚洲黑色素瘤不同临床表现的认识，并鼓励检查手掌和脚底，以减少诊断延误。
INTRODUCTION Cutaneous melanoma is rare in Asia and the clinical presentation and outcome of melanoma is not well described in Southeast Asia. In addition, it is unclear if ethnic variations exist between the various racial groups. The objective of our study is to present the clinical characteristics of melanoma in Singapore and to highlight ethnical differences between Asians and Caucasians living in Singapore. MATERIALS AND METHODS Data were retrospectively collected from 48 patients with histological confirmation of melanoma who were seen in both the National Skin Centre and National Cancer Centre of Singapore. RESULTS Acral lentiginous melanoma (ALM) was the most common subtype of melanoma in Singapore (50%). A higher proportion of non-ALM subtypes of melanoma compared to ALM were diagnosed at stage 1 (48% vs. 25%). The delay in diagnosis of ALM was 27 months compared to 12 months in other subtypes. Compared to Caucasians, there was a trend towards Asian patients being older, having a higher proportion of ALM and a longer delay to diagnosis. CONCLUSION Geographical and ethnic variations in the clinical presentation of melanoma exist. Specially adapted programmes are necessary to increase awareness of the different clinical presentation of melanoma in Asia and to encourage examination of the palms and soles in order to reduce the delay in diagnosis.