Biological basis of bone formation, remodeling, and repair - Part III: Biomechanical forces
Biological basis of bone formation, remodeling, and repair - Part III: Biomechanical forces
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DOI：
10.1089/ten.teb.2008.0084
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发表时间：
2008-09-01
影响因子：
6.4
通讯作者：
Warren, Stephen M.
中科院分区：
文献类型：
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作者：
Allori, Alexander C.;Sailon, Alexander M.;Warren, Stephen M.
虽然长期以来人们一直认为生物力学力量参与了骨的重建和修复，但物理力量转化为相应的细胞内信号的实际机制在很大程度上仍然是一个谜。到目前为止，大多数生物力学研究都集中在对骨形态和结构的影响上，以及。直到最近，才描述了参与这一过程的复杂的细胞和分子途径(称为机械转导)。在本文中，我们回顾了目前对骨机械生物学的了解，并强调了其对临床医学和组织工程研究的意义。
While it has been long appreciated that biomechanical forces are involved in bone remodeling and repair, the actual mechanism by which a physical force is translated to the corresponding intracellular signal has largely remained a mystery. To date, most biomechanical research has concentrated upon the effect on bone morphology and architecture, and. it is only recently that the complex cellular and molecular pathways involved in this process (called mechanotransduction) are being described. In this paper, we review the current understanding of bone mechanobiology and highlight the implications for clinical medicine and tissue engineering research.