Minimizing material damage using low temperature irradiation
Minimizing material damage using low temperature irradiation
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DOI：
10.1016/j.radphyschem.2012.01.013
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发表时间：
2012-08-01
影响因子：
2.9
通讯作者：
Winters, M.
中科院分区：
文献类型：
--
作者：
Craven, E.;Hasanain, F.;Winters, M.
技术突破和人口老龄化和日益肥胖推动了医疗保健领域的科学进步，导致医疗器械市场不断变化。复杂的产品和设备正在开发中，以满足前沿医疗程序的需求。这些医疗设备中的特殊材料，包括药物和生物制品以及外来聚合物，对辐射灭菌提出了挑战，因为这些组件中的许多组件无法承受传统的辐照方法。在干冰温度下辐照材料已成为一种可用于降低材料辐射敏感性的技术，本研究的目的是研究低温辐照对各种聚合物材料的影响，并在0 ℃至-80 ℃的温度范围内。在这些条件下的微生物杀灭的有效性也被调查，研究的结果表明，低温照射的效果是材料依赖性的，可以改变交联和断链的聚合物之间的平衡。低温也会增加达到等效微生物杀灭所需的剂量，因此必须在使用环境条件下进行剂量设定练习。(C)2012爱思唯尔有限公司保留所有权利。
Scientific advancements in healthcare driven both by technological breakthroughs and an aging and increasingly obese population have lead to a changing medical device market. Complex products and devices are being developed to meet the demands of leading edge medical procedures.Specialized materials in these medical devices, including pharmaceuticals and biologics as well as exotic polymers present a challenge for radiation sterilization as many of these components cannot withstand conventional irradiation methods. The irradiation of materials at dry ice temperatures has emerged as a technique that can be used to decrease the radiation sensitivity of materials.The purpose of this study is to examine the effect of low temperature irradiation on a variety of polymer materials, and over a range of temperatures from 0 degrees C down to -80 degrees C. The effectiveness of microbial kill is also investigated under each of these conditions.The results of the study show that the effect of low temperature irradiation is material dependent and can alter the balance between crosslinking and chain scission of the polymer. Low temperatures also increase the dose required to achieve an equivalent microbiological kill, therefore dose setting exercises must be performed under the environmental conditions of use. (C) 2012 Elsevier Ltd. All rights reserved.