Image-guided Adaptive Radiotherapy for Bladder Cancer
Image-guided Adaptive Radiotherapy for Bladder Cancer
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DOI：
10.1016/j.clon.2021.03.023
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发表时间：
2021-05-07
影响因子：
3.4
通讯作者：
Hafeez, S.
中科院分区：
文献类型：
--
作者：
Kong, V;Hansen, V. N.;Hafeez, S.
技术进步促进了膀胱癌患者特异性放射治疗。影像引导放射治疗（IGRT）的发展使这成为可能。尤其具有变革意义的是将体积成像集成到工作流程中。使用锥形束计算机断层扫描和磁共振成像来观察膀胱目标的能力最初有助于确定分数间和分数内目标变化的大小。它使人们更有信心确定每个部分的真实解剖结构。给膀胱的剂量增加了确定性，使得计划靶体积边界的安全减小成为可能。因此，IGRT通过减少对周围组织的整体剂量改善了靶标覆盖率。根据当天的解剖结构，使用IGRT反馈到计划和剂量递送优化中，使自适应放疗膀胱解决方案成为可能。在此，我们对体外束流膀胱癌放疗的IGRT和适应性放疗策略的逐步发展进行了综述。我们根据放射肿瘤学技术创新的系统临床评估框架（R-IDEAL）提出证据。(c) 2021皇家放射科医师学院。Elsevier Ltd.出版。这是一篇基于CC BY-NC-ND许可（http://creativecommons.org/ licenses/by-nc- and /4.0/）的开放获取文章。
Technological advancement has facilitated patient-specific radiotherapy in bladder cancer. This has been made possible by developments in image-guided radiotherapy (IGRT). Particularly transformative has been the integration of volumetric imaging into the workflow. The ability to visualise the bladder target using cone beam computed tomography and magnetic resonance imaging initially assisted with determining the magnitude of inter-and intra-fraction target change. It has led to greater confidence in ascertaining true anatomy at each fraction. The increased certainty of dose delivered to the bladder has permitted the safe reduction of planning target volume margins. IGRT has therefore improved target coverage with a reduction in integral dose to the surrounding tissue. Use of IGRT to feed back into plan and dose delivery optimisation according to the anatomy of the day has enabled adaptive radiotherapy bladder solutions. Here we undertake a review of the stepwise developments underpinning IGRT and adaptive radiotherapy strategies for external beam bladder cancer radiotherapy. We present the evidence in accordance with the framework for systematic clinical evaluation of technical innovations in radiation oncology (R-IDEAL).(c) 2021 The Royal College of Radiologists. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).