Prenatal Exposures to Perfluoroalkyl Acids and Associations with Markers of Adiposity and Plasma Lipids in Infancy: An Odense Child Cohort Study
Prenatal Exposures to Perfluoroalkyl Acids and Associations with Markers of Adiposity and Plasma Lipids in Infancy: An Odense Child Cohort Study
复制标题
DOI：
10.1289/ehp5184
复制
发表时间：
2020-07-01
影响因子：
10.4
通讯作者：
Jensen, Tina Kold
中科院分区：
文献类型：
--
作者：
Jensen, Richard Christian;Andersen, Marianne S.;Jensen, Tina Kold
背景：全氟烷基酸（PFAA）是能够穿过胎盘屏障的排斥剂，能够干扰胎儿编程。母体PFAA浓度与儿童和成年期的后代肥胖和血脂异常相关，但这种相关性在婴儿期尚未研究过。对649名妇女进行了全氟己烷磺酸（PFHxS）、全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟壬酸（PFNA）和全氟癸酸（PFDA）的测定。在出生时（n = 613）和3个月（n =602）和18个月（n =503）时检查后代。在3个月龄（n = 262）和18个月龄（n =198）时评价总胆固醇、LDL、HDL和甘油三酯。混合效应线性回归模型估计PFAA与标准化（SDS）体重指数（BMI）、体重指数和腰围之间的相关性。结果：PFNA和PFDA与3月龄和18月龄的BMI SDS（校正后）相关，PFNA和PFDA与3月龄和18月龄的BMI SDS（校正后）相关（β =0.26; 95%置信区间（CI）：0.03，0.49和β =0.58; 95% CI：-0.03，1.19，增加1 ng/mL）和重量指数SDS（β =0.36; 95% CI：0.13，0.59和β =1.02; 95% CI：0.40，1.64）。男孩的相应估计值更接近零，但与女孩的估计值无显著差异。在男孩和女孩PFNA和PFDA与3个月龄时的BF%相关（对于1 ng/mL PFDA，（β =0.40; 95% CI：0.04，0.75），PFDA与18个月时的总胆固醇SDS相关（β =1.06; 95%CI：0.08，2.03）（n = 83）.讨论：产前PFAA与婴儿期肥胖和高总胆固醇的纵向标志物正相关。鉴于儿童超重和血脂异常的比例不断上升，这些发现值得关注。
BACKGROUND: Perfluoroalkyl acids (PFAA) are repellants that cross the placental barrier, enabling interference with fetal programming. Maternal PFAA concentrations have been associated with offspring obesity and dyslipidemia in childhood and adulthood, but this association has not been studied in infancy.OBJECTIVES: We investigated associations between maternal PFAA concentrations and repeated markers of adiposity and lipid metabolism in infancy.METHODS: In the prospective Odense Child Cohort, maternal pregnancy serum concentrations of five PFAA: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluomdecanoic acid (PFDA) were measured in 649 women. Offspring were examined at birth (n = 613) and at 3 months (n =602) and 18 months (n =503) of age. Total cholesterol, LDL, HDL, and triglyceride were evaluated at 3 months (n = 262) and 18 months (n =198) of age. Mixed effects linear regression models estimated associations between PFAA and standardized (SDS) body mass index (BMI), ponderal index, and waist circumference. Associations between PFAA and body fat% (BF%) and plasma lipids SDS at 3 months and 18 months of age were investigated with linear regression models.RESULTS: PFNA and PFDA were associated with higher BMI SDS [adjusted (beta=0.26; 95% confidence interval (CI): 0.03, 0.49 and beta=0.58; 95% CI: -0.03, 1.19, respectively, for 1-ng/mL increases] and ponderal index SDS (beta=0.36; 95% CI: 0.13, 0.59 and beta=1.02; 95% CI: 0.40, 1.64, respectively) at 3 and 18 months of age (pooled) in girls. Corresponding estimates for boys were closer to the null but not significantly different from esti-mates for girls. In boys and girls (combined), PFNA and PFDA were associated with BF% at age 3 months (for 1-ng/mL PFDA, (beta=0.40; 95% CI: 0.04, 0.75), and PFDA was associated with total cholesterol SDS at 18 months (beta=1.06; 95% CI: 0.08, 2.03) (n = 83).DISCUSSION: Prenatal PFAA were positively associated with longitudinal markers of adiposity and higher total cholesterol in infancy. These findings deserve attention in light of rising rates of childhood overweight conditions and dyslipidemia.