Longitudinal trajectories of behavior problems and social competence in children with new onset epilepsy.
Longitudinal trajectories of behavior problems and social competence in children with new onset epilepsy.
复制标题
新发癫痫儿童行为问题和社交能力的纵向轨迹。
DOI：
10.1111/dmcn.12549
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发表时间：
2015
影响因子：
3.8
通讯作者：
Hermann,BruceP
中科院分区：
文献类型：
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作者：
Zhao,Qianqian;Rathouz,PaulJ;Jones,JanaE;Jackson,DarenC;Hsu,DavidA;Stafstrom,CarlE;Seidenberg,Michael;Hermann,BruceP
目的探讨新发或近期癫痫患儿自确诊至确诊后5 ~ 6年父母报告的行为和社会能力问题与健康对照者的前瞻性发展轨迹。方法35例新发/近期发病的特发性全身性（IGE）患儿（男性21例，女性14例，平均年龄14岁1个月[SD 3岁4个月]范围8 - 18岁）和34例定位相关性癫痫患儿（LRE，男性19例，女性15例，平均年龄10岁8个月[SD 2岁2个月]范围8 - 18岁）在诊断后基线、2年和5 - 6年接受行为评估（儿童行为检查表）。评估包括总行为问题、内化问题、外化问题和总胜任力三个综合量表。62名发育正常的儿童作为比较参与者。分析基于随机效应回归模型，比较各组癫痫诊断以来的时间轨迹。结果LRE和IGE综合征组与健康对照组之间的父母报告的行为问题差异在诊断时或接近诊断时可检测到，并且在随后的5至6年中保持稳定（能力）或倾向于减轻（行为问题），没有渐进式恶化的证据。这些趋势在LRE组和IGE组中都很明显，两者之间没有差异。LRE和IGE患儿的行为和能力问题在5 - 6年的时间内没有进行性恶化的特征。行为问题在诊断时出现，并随着时间的推移而逐渐减轻，能力问题在一系列评估中更加持久，并且在LRE和IGE组中都存在。
AimTo characterize the prospective trajectory of parent‐reported behavior and social competence problems in children with new or recent onset epilepsy from diagnosis to 5 to 6 years after diagnosis compared to healthy control participants.MethodThirty‐five children (21 males, 14 females; mean age 14y 1mo [SD 3y 4mo] range 8–18y) with new/recent onset idiopathic generalized (IGE) and 34 children with localization‐related epilepsies (LRE; 19 males, 15 females; mean age 10y 8mo [SD 2y 2mo] range 8–18y) underwent behavioral assessment (Child Behavior Checklist) at baseline, 2 years, and 5 to 6 years after diagnosis. The assessment comprised the summary scales Total Behavior Problems Internalizing Problems, Externalizing Problems, and Total Competence. Sixty‐two children with normal development served as comparison participants. Analyses were based on random effects regression modeling comparing trajectories with respect to time since epilepsy diagnosis among groups.ResultsDifferences in parent‐reported behavioral problems between LRE and IGE syndrome groups and healthy comparison participants were detectable at or near the time of diagnosis and remained either stable (competence) or tended to abate (behavior problems) over the ensuing 5 to 6 years without evidence of progressive worsening. These trends were evident for both LRE and IGE groups, with no differences between them.InterpretationBehavior and competence problems in children with LRE and IGE are not characterized by progressive worsening over a 5‐ to 6‐year period. Behavioral problems are present near the time of diagnosis and tend to abate over time, with competence problems being more persistent across serial assessments, and present in both LRE and IGE groups.