Optimizing the CAMCOG test in the screening for mild cognitive impairment and incipient dementia: saving time with relevant domains
Optimizing the CAMCOG test in the screening for mild cognitive impairment and incipient dementia: saving time with relevant domains
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DOI：
10.1002/gps.2540
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发表时间：
2011-04-01
影响因子：
4
通讯作者：
Forlenza, Orestes Vicente
中科院分区：
文献类型：
--
作者：
Aprahamian, Ivan;Diniz, Breno Satler;Forlenza, Orestes Vicente
目的：确定在临床实践中对轻度认知障碍(MCI)和早期阿尔茨海默病(AD)患者的识别最有帮助的CAMCOG亚项。方法：采用标准化神经心理成套测验和CAMCOG量表对272名老年人(98名MCI、82名AD和92名对照)进行横断面评估。以诊断(MCI和对照组)为因变量，CAMCOG各子项为自变量，进行Logistic回归分析，确定预测MCI诊断的CAMCOG子项。结果：语言、记忆、实践、计算4个子项得分较低与MCI的诊断显著相关。这些分数的总和得到的综合分数显著区分了MCI患者和对照组。与对照组相比，简化后的CAMCOG对MCI患者的诊断准确率与原始CAMCOG相似(AUC=0.80+/-0.03；原始CAMCOG的AUC=0.79+/-0.03)。结论：简化后的CAMCOG具有与原始CAMCOG相似的诊断特性，且操作更快、更容易，更适合于一般临床实践中对细微认知障碍的筛查。版权所有(C)2010 John Wiley&Sons，Ltd.
Objective: To identify the CAMCOG sub-items that best contribute for the identification of patients with mild cognitive impairment (MCI) and incipient Alzheimer's disease (AD) in clinical practice.Methods: Cross-sectional assessment of 272 older adults (98 MCI, 82 AD, and 92 controls) with a standardized neuropsychological battery and the CAMCOG schedule. Backward logistic regression analysis with diagnosis (MCI and controls) as dependent variable and the sub-items of the CAMCOG as independent variable was carried out to determine the CAMCOG sub-items that predicted the diagnosis of MCI.Results: Lower scores on Language, Memory, Praxis, and Calculation CAMCOG sub-items were significantly associated with the diagnosis of MCI. A composite score obtained by the sum of these scores significantly discriminated MCI patients from comparison groups. This reduced version of the CAMCOG showed similar diagnostic accuracy than the original schedule for the identification of patients with MCI as compared to controls (AUC = 0.80 +/- 0.03 for the reduced CAMCOG; AUC = 0.79 +/- 0.03 for the original CAMCOG).Conclusion: This reduced version of the CAMCOG had similar diagnostic properties as the original CAMCOG and was faster and easier to administer, rendering it more suitable for the screening of subtle cognitive deficits in general clinical practice. Copyright (C) 2010 John Wiley & Sons, Ltd.