Pressor responses to isometric biting are evoked by somatosensory receptors in periodontal tissue in humans
Pressor responses to isometric biting are evoked by somatosensory receptors in periodontal tissue in humans
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DOI：
10.1152/japplphysiol.91199.2008
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发表时间：
2009-08-01
影响因子：
3.3
通讯作者：
Nose, Hiroshi
中科院分区：
文献类型：
--
作者：
Okada, Yoshiyuki;Kamijo, Yoshi-ichiro;Nose, Hiroshi
等长咬合引起的升压反应是由牙周组织中的体感受体引起的。应用生理学杂志107：531-539,2009。2009年5月28日首次出版；doi：10.1152/japplPhysiol.91199.2008。-下颌肌肉收缩，如咀嚼和咬合(BT)，已知会引起升压反应。我们检查了这些反应是否由牙周组织中的体感受体引起，而且，它们是否伴随着动脉压力感受器敏感性的改变。在第一个实验中，我们测量了8名年轻人在药物肺泡神经阻滞(BLK)前和药物肺泡神经阻滞(BLK)前2min等长BT时腓神经的平均动脉压、心率和肌交感神经活动，同时监测手指皮肤血管电导、牙龈血管电导(GVC)、咬肌表面肌电和BT力。在第二个实验中，分别有8名和5名受试者用改良的牛津法测定了CNT和BLK的心脏和交感压力感受性反射的敏感性。在第一个实验中，尽管CNT和BLK的BT显著增加平均动脉压、心率和总肌交感神经活动(爆发幅度x爆发发生率)，并降低手指皮肤血管传导性和GVC(P<；0.05)，但BLK组除GVC外的所有变化均显著减弱(P<；0.05)。各试验间积分肌电和BT力差异均无统计学意义。在第二个实验中，尽管CNT的BT显著降低了心脏和交感压力反射的敏感性(P<；0.05)，但BLK的这些变化消失了。这些结果提示，牙周组织中的体感受体参与了等长BT的升压反应，并伴随着动脉压力感受性反射敏感性的降低。
Okada Y, Kamijo Y, Okazaki K, Masuki S, Goto M, Nose H. Pressor responses to isometric biting are evoked by somatosensory receptors in periodontal tissue in humans. J Appl Physiol 107: 531-539, 2009. First published May 28, 2009; doi: 10.1152/japplphysiol.91199.2008.-Jaw muscle contraction, such as mastication and biting (BT), is known to evoke pressor responses. We examined whether the responses were evoked by somatosensory receptors in periodontal tissue and, moreover, whether they were accompanied by altered arterial baroreflex sensitivity. In the first experiment, we measured mean arterial pressure, heart rate, and muscle sympathetic nerve activity from the peroneal nerve during 2-min isometric BT at 50% maximal voluntary contraction before [control (CNT)] and after pharmacological alveolar nerve block (BLK) in eight young men, while monitoring finger cutaneous vascular conductance, gingival vascular conductance (GVC), surface electromyogram of masseter muscle, and BT force. In the second experiment, cardiac and sympathetic baroreflex sensitivities were successfully determined in eight and five of the subjects, respectively, by the modified Oxford method during 5-min BT at 30% maximal voluntary contraction and also during resting without BT in CNT and BLK, respectively. In the first experiment, although BT in CNT and BLK significantly increased mean arterial pressure, heart rate, and total muscle sympathetic nerve activity (burst amplitude x burst incidence), and decreased finger cutaneous vascular conductance and GVC (P < 0.05), all changes except GVC were markedly attenuated in BLK (P < 0.05). There were no significant differences in integrated electromyogram and BT force among any trials. In the second experiment, although BT in CNT significantly decreased cardiac and sympathetic baroreflex sensitivities (both, P < 0.05), these changes disappeared in BLK. These results suggest that somatosensory receptors in periodontal tissue were involved in pressor responses to isometric BT, which was accompanied by decreased arterial baroreflex sensitivity.