SARS-CoV-2 has displaced other seasonal respiratory viruses: Results from a prospective cohort study.
SARS-CoV-2 has displaced other seasonal respiratory viruses: Results from a prospective cohort study.
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DOI：
10.1016/j.jinf.2020.11.010
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Clark TW
中科院分区：
文献类型：
--
作者：
Poole S;Brendish NJ;Clark TW
其他呼吸道病毒的发病率在第一个高峰期急剧下降。SARS-CoV-2很少与其他呼吸道病毒同时检出。SARS-CoV-2很少与COPD或哮喘加重相关。与其他病毒相比，COVID-19患者的死亡率要高得多。SARS-CoV-2对循环中现有呼吸道病毒的影响以及病毒性呼吸道疾病的总体负担仍不确定。传统上，严重的病毒性呼吸道疾病会影响那些患有潜在慢性肺部疾病的人。本研究旨在评估SARS-CoV-2对住院成人呼吸道病毒疾病患病率和临床特征的影响。这项队列研究的数据来自英国汉普郡的住院成人，他们在几个季节进行了呼吸道病毒的多重PCR检测。将SARS-CoV-2第一个流行高峰期间的呼吸道病毒检测与前几年同期的检测进行比较。在5年的3月至5月期间，对856例患者进行了呼吸道病毒多重PCR检测。在2020年之前，在54%的患者（202/371）中检测到非SARS-CoV-2病毒，而2020年为4.1%（20/485）（p <0.0001）。与其他病毒相比，SARS-CoV-2与哮喘或COPD急性加重相关的感染患者比例较小（1.0% vs 37%，p <0.0001）。SARS-CoV-2的出现与季节性呼吸道病毒循环的大幅减少以及病毒相关疾病特征的巨大差异有关，包括更大比例的无基础肺部疾病的患者患病。
The incidence of other respiratory viruses fell dramatically during the first peak. SARS-CoV-2 was rarely co-detected with other respiratory viruses. SARS-CoV-2 was infrequently associated with exacerbations of COPD or asthma. Mortality rate was much higher in patients with COVID-19 compared to other viruses. The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults. Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years. 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001). The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.
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影响因子：
168.9
作者：
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通讯作者：
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DOI：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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