Treatment of Male Infertility
Treatment of Male Infertility
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DOI：
10.1007/978-1-4939-0659-8_18
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Rosenwaks, Zev
中科院分区：
文献类型：
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作者：
Palermo, Gianpiero D.;Kocent, Justin;Rosenwaks, Zev
在准确和有意义的诊断男性生殖功能障碍方面存在主要困难，我们对男性不育的流行病学和病因学的了解已经被证明是相当复杂的。哺乳动物和其他物种产生的大量精子可以在一定程度上保护人们免受恶劣环境条件的影响，这些环境因素会降低生殖功能，增加性腺损伤，甚至导致睾丸癌或先天性畸形。男性精子产量的大幅波动，无论是在地理上还是在时间上，可能反映了不同的环境暴露，发生在不同的遗传背景，不同的心理社会条件，并导致了多样化的观察结果。精子分析仍然是诊断男性因素不育的基石，实际上，在充分解决治疗实践的同时，精子分析仍然是诊断男性因素不育的基石，同时还在逐步进行额外的测试。给药、人工授精、纠正精索静脉曲张，以及在一定程度上的试管受精，尽管它们本身可能不能恢复生育能力，但往往会导致生育。
Major difficulties exist in the accurate and meaningful diagnosis of male reproductive dysfunction, and our understanding of the epidemiology and etiology of male infertility has proven quite complex.The numerous spermatozoa produced in mammals and other species provides some degree of protection against adverse environmental conditions represented by physical and chemical factors that can reduce reproductive function and increase gonadal damage even resulting in testicular cancer or congenital malformations. The wide fluctuations of sperm production in men, both geographical and temporal, may reflect disparate environmental exposures, occurring on differing genetic backgrounds, in varying psychosocial conditions, and leading to the diversified observed outcomes.Sperm analysis is still the cornerstone in diagnosis of male factor infertility, indeed, individually compromised semen paramaters while adequately address therapeutic practices is progressively flanked by additional tests. Administration of drugs, IUI, correction of varicocele, and, to a certain extent, IVF although they may not be capable of restoring fertility itself often result in childbearing.