Emerging themes in bacterial autophagy.
Emerging themes in bacterial autophagy.
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DOI：
10.1016/j.mib.2014.11.020
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发表时间：
2015-02
影响因子：
5.4
通讯作者：
M. Sorbara;S. Girardin
中科院分区：
文献类型：
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作者：
M. Sorbara;S. Girardin
HighlightsHow细菌靶向是在异种吞噬中实现的。细菌病原体是如何引发自噬的。异食在细菌限制中的作用。细菌病原体如何逃避自噬。自噬在控制胞内细菌病原体中的作用，也被称为异体噬，是有充分记录的。在此，我们重点介绍异种噬体领域的最新进展。本文综述了泛素化、二酰基甘油（DAG）或Nod1、Nod2、NDP52、p62、NBR1、optinurin、LRSAM1和parkin等蛋白在异种吞噬过程中的作用。代谢传感器，如mTOR和AMPK，在异种噬诱导的重要性也进行了讨论。我们还回顾了体外和体内的证据，证明了异种噬在控制细菌生长中的全局作用。最后，介绍了细菌为逃避异食而进化的机制。
HighlightsHow bacterial targeting is achieved in xenophagy.How autophagy is triggered by bacterial pathogens.The role of xenophagy in bacterial restriction.How bacterial pathogens escape autophagy.The role of autophagy in the control of intracellular bacterial pathogens, also known as xenophagy, is well documented. Here, we highlight recent advances in the field of xenophagy. We review the importance of bacterial targeting by ubiquitination, diacylglycerol (DAG) or proteins such as Nod1, Nod2, NDP52, p62, NBR1, optineurin, LRSAM1 and parkin in the process of xenophagy. The importance of metabolic sensors, such as mTOR and AMPK, in xenophagy induction is also discussed. We also review the in vitro and in vivo evidence that demonstrate a global role for xenophagy in the control of bacterial growth. Finally, the mechanisms evolved by bacteria to escape xenophagy are presented.