Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatment
Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatment
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DOI：
10.1016/j.jmmm.2005.01.081
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发表时间：
2005-05-01
影响因子：
2.7
通讯作者：
Strachan, NJC
中科院分区：
文献类型：
--
作者：
Rotariu, O;Strachan, NJC
位于人体腔中的肿瘤的磁性药物靶向是困难的，因为磁梯度随着与磁体的距离而迅速减小。在这里，计算机模拟被用来研究不同的技术，以集中在肿瘤的微血管内的小MP。发现非侵入性方法的范围<15 cm，而微创方法可专门应用于小肿瘤（<18 mm）。(c)2005年由Elsevier B.V.出版
Magnetic drug targeting of tumors situated in the cavity of the human body is difficult because the magnetic gradients decrease rapidly with the distance from the magnets. Here computer simulations are used to investigate different techniques to focus small MPs within the microvasculature of tumors. Non-invasive methods were found to have range < 15 cm whilst minimal invasive methods could be applied specifically to small tumors (< 18 mm). (c) 2005 Published by Elsevier B.V.