Effects of Environmental Factors on Severity and Mortality of COVID-19.
Effects of Environmental Factors on Severity and Mortality of COVID-19.
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环境因素对 COVID-19 严重程度和死亡率的影响。
DOI：
10.3389/fmed.2020.607786
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发表时间：
2020
影响因子：
3.9
通讯作者：
Lauc G
中科院分区：
文献类型：
--
作者：
Kifer D;Bugada D;Villar-Garcia J;Gudelj I;Menni C;Sudre C;Vučković F;Ugrina I;Lorini LF;Posso M;Bettinelli S;Ughi N;Maloberti A;Epis O;Giannattasio C;Rossetti C;Kalogjera L;Peršec J;Ollivere L;Ollivere BJ;Yan H;Cai T;Aithal GP;Steves CJ;Kantele A;Kajova M;Vapalahti O;Sajantila A;Wojtowicz R;Wierzba W;Krol Z;Zaczynski A;Zycinska K;Postula M;Lukšić I;Čivljak R;Markotić A;Brachmann J;Markl A;Mahnkopf C;Murray B;Ourselin S;Valdes AM;Horcajada JP;Castells X;Pascual J;Allegri M;Primorac D;Spector TD;Barrios C;Lauc G
背景：大多数呼吸道病毒表现出明显的季节性，但对于SARS-CoV-2，这一点仍需记录在案。方法：对6,914名在欧洲和中国医院住院的患者进行新冠肺炎的疾病进展情况的检测。此外，我们评估了37187名将症状报告到COVID症状研究应用程序中的疾病症状的进展情况。结果：对七家欧洲医院的死亡风险进行的荟萃分析估计，入院日期每增加1天的优势比为0.981(0.973-0.988，p<；0.001)，环境温度每增加1℃的优势比为0.854(0.773-0.944，p=0.007)。在大多数医院，但不是所有医院，在中位住院时间、转到重症监护病房的可能性以及需要机械通风方面也观察到了统计上显著的下降。对英国37187人的个人报告症状的分析也表明，症状持续时间和疾病严重程度随着时间的推移而减少。解读：新冠肺炎在欧洲的严重程度在3-5月明显下降，新冠肺炎的季节性是最可能的解释。
Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973–0.988, p < 0.001) and per increase in ambient temperature of 1°C to be 0.854 (0.773–0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.