Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies.
Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies.
复制标题
DOI：
10.18632/oncotarget.20136
复制
发表时间：
2017-11-28
期刊：
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Augsburger D;Nelson PJ;Kalinski T;Udelnow A;Knösel T;Hofstetter M;Qin JW;Wang Y;Gupta AS;Bonifatius S;Li M;Bruns CJ;Zhao Y
成人型纤维肉瘤是一种罕见且高度侵袭性的软组织肉瘤亚型。由于存在其他梭形细胞肉瘤，其诊断一直是一个排除。相似肿瘤实体之间误诊的可能性很高，并且经常导致不适当的肿瘤治疗。我们在这里总结纤维肉瘤的主要特点。当纤维肉瘤被正确诊断时，患者的总体预后通常很差。纤维肉瘤的特点是对放疗和化疗的敏感性低，肿瘤复发率高。因此，重要的是要确定新的方法来改善这种肿瘤实体的治疗。我们讨论了纤维肉瘤研究中一些有前途的新方向，特别关注更有效地靶向肿瘤微环境。肿瘤细胞与其周围基质组织之间的通讯在癌症进展、侵袭、转移和化疗敏感性中起着至关重要的作用。靶向肿瘤微环境的治疗潜力得到解决。
Adult-type fibrosarcoma is a rare and highly aggressive subtype of soft tissue sarcomas. Due to the existence of other spindle-cell shaped sarcomas, its diagnosis is always one of exclusion. The likelihood of misdiagnoses between similar tumour entities is high, and often leads to inappropriate tumour treatment. We summarize here the main features of fibrosarcoma. When fibrosarcoma is appropriately diagnosed, the patient`s overall prognosis is generally quite poor. Fibrosarcoma is characterized by its low sensitivity towards radio- and chemotherapy as well as by its high rate of tumour recurrences. Thus it is important to identify new methods to improve treatment of this tumour entity. We discuss some promising new directions in fibrosarcoma research, specifically focusing on more effective targeting of the tumour microenvironment. Communication between tumour cells and their surrounding stromal tissue play a crucial role in cancer progression, invasion, metastasis and chemosensitivity. The therapeutic potential of targeting the tumour microenvironment is addressed.