The role of Leucocyte-rich and platelet-rich fibrin (L-PRF) in the treatment of the medication-related osteonecrosis of the jaws (MRONJ).
The role of Leucocyte-rich and platelet-rich fibrin (L-PRF) in the treatment of the medication-related osteonecrosis of the jaws (MRONJ).
复制标题
DOI：
10.4317/jced.54154
复制
发表时间：
2017-08-01
影响因子：
--
通讯作者：
Lopez-Quiles, Juan
中科院分区：
文献类型：
--
作者：
Cano-Duran, Jorge A;Pena-Cardelles, Juan-Francisco;Lopez-Quiles, Juan
背景技术背景：对于双膦酸盐和其他药物相关的颌骨骨坏死的治疗，目前已建立了不同的保守治疗方法，避免手术，除非在极端需要的情况下，药物相关的颌骨骨坏死（MRONJ）。鉴于关于患者的MRONJ治疗的争议和当前缺乏共识，已经开发了新技术，其中使用富含血小板和白细胞的纤维蛋白膜（L-PRF）。本综述的目的是评估L-PRF治疗是否真的有效，以及这种治疗方法可以实现的结果。材料和方法：在PubMed/Medline数据库中使用L-PRF治疗骨坏死的所有研究的文献综述，使用关键词“骨坏死”，“大白鲨”，“L-PRF”和“富含白细胞的血小板丰富的纤维蛋白“。使用L-PRF治疗MRONJ确实有效，特别是当同时应用L-PRF和形态发生蛋白-2（BMP-2）时，即使在长期接受静脉双膦酸盐治疗的患者中也是如此。然而，成功将取决于几个因素，如以前存在的感染或临床阶段，其中patientis.CONCLUSIONS：目前的文献表明，使用L-PRF在骨坏死的有效性，它可以被认为是一个真实的替代治疗这个实体。然而，需要更多的临床研究来真正评估这种新疗法。关键词：骨坏死，颌骨，L-PRF，富白细胞富血小板纤维蛋白。
BACKGROUND: For the treatment of the bisphosphonates and other drugs related osteonecrosis of the jaws, currently medication-related osteonecrosis of the jaws (MRONJ), have been established different conservative therapeutic approaches, avoiding surgery except in cases of extreme need. Given the controversy and lack of current consensus regarding MRONJ therapy in patients, new techniques have been developed among which the use of fibrin membranes rich in platelets and leukocytes (L-PRF). The objective of this review is to evaluate whether L-PRF treatment is really effective, as well as the results that can be achieved by this therapeutic alternative.MATERIAL AND METHODS: A review of the literature in the PubMed/Medline database of all those studies using L-PRF in the treatment of osteonecrosis using the keywords "Osteonecrosis", "Jaws", "L-PRF" and " Leucocyte-rich platelet-rich fibrin ".RESULTS: The use of L-PRF for the treatment of MRONJ is really effective, especially when it is performed with a simultaneous application of L-PRF and morphogenetic protein-2 (BMP-2), even in patients submitted for long periods of time to therapy with intravenous bisphosphonates. However, success will depend on several factors such as the previous existence of infection or the clinical stage in which the patient is.CONCLUSIONS: The current literature demonstrates the effectiveness of the use of L-PRF in osteonecrosis, and it can be considered as a real alternative in the treatment of this entity. However, more clinical studies are needed to really assess this new therapy. Key words:Osteonecrosis, Jaws, L-PRF, Leucocyte-rich platelet-rich fibrin.