NON-ST-Segment Elevation Myocardial Infarction Associated with Inadvertent Thyroid Hormone Overdose
NON-ST-Segment Elevation Myocardial Infarction Associated with Inadvertent Thyroid Hormone Overdose
复制标题
与无意的甲状腺激素过量相关的非 ST 段抬高型心肌梗死
DOI：
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Samy I McFarlane
中科院分区：
文献类型：
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作者：
A. Doodnauth;Fadi Yacoub;Vaibhavi Solanki;Andrea Trimmingham;Lina Soni;Samy I McFarlane
甲状腺激素在心血管功能和心脏血流动力学中起着重要作用。甲状腺的轻微变化会影响心室功能、血清胆固醇水平，增加冠状动脉疾病和心血管疾病死亡率的风险。在本报告中，我们报告了一位62岁的女性，她有明显的缺血性心脏病病史，因急性冠状动脉综合征（ACS）合并持续性心动过速而入院，需要紧急心导管插入术。完整的心脏检查显示，患者极有可能因无意中过量服用左甲状腺素而患上血管痉挛性心绞痛。本报告强调明显甲状腺功能亢进继发的肾上腺素能亢进状态引起的显著心脏并发症。我们的结论是，甲状腺毒症是心血管疾病的重要危险因素，应被视为危及生命的心肌缺血的原因，特别是在已知的缺血性心脏病和甲状腺疾病患者中。
Thyroid hormone has a major role in cardiovascular function and cardiac hemodynamics. A slight change in thyroid affects ventricular function, serum cholesterol levels, increases the risk of coronary artery disease as well as cardiovascular mortality. In this report, we present a 62-year-old female with history significant for ischemic heart disease who was admitted for acute coronary syndrome (ACS) with persistent tachycardia, requiring urgent cardiac catheterization. Complete cardiac workup revealed that the patient had most likely suffered from vasospastic angina secondary to inadvertent overdose of her prescribed levothyroxine. This report emphasizes the significant cardiac complications caused by a deluged hyperadrenergic state secondary to overt hyperthyroidism. We conclude that thyrotoxicosis is a significant risk factor for cardiovascular disease and should be considered as a cause of life-threatening myocardial ischemia, especially in patients with known ischemic heart disease and thyroid disorders.