Physiologic changes in serotonin concentrations in breast milk during lactation
Physiologic changes in serotonin concentrations in breast milk during lactation
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哺乳期母乳中血清素浓度的生理变化
DOI：
10.1016/j.nut.2020.110969
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发表时间：
2020-11-01
期刊：
影响因子：
4.4
通讯作者：
Chiba, Takeshi
中科院分区：
文献类型：
--
作者：
Maeda, Tomoji;Shioyama, Aki;Chiba, Takeshi
目的：5-羟色胺（5-HT）在哺乳期乳腺的乳量平衡中起着重要作用，并且乳中的5-HT也可能影响婴儿的发育。本研究的目的是调查母乳中5-HT浓度的变化，根据哺乳期的持续时间，并评估5-HT浓度是否变化前后nursed.Methods：健康护理日本妇女谁有自然分娩或接受剖腹产在岩手医科大学医院纳入本研究。从分娩后6至7天的经产母亲（初乳）中获得乳汁中的平均5-HT浓度，与经产母亲相比显著更高（24.3 +/- 2.63 vs 18.5 +/- 2.60 ng/mL）。此外，平均5-HT浓度随着泌乳期的增加而增加（初乳：18.5 +/- 2.60;分娩后1个月：19.8 +/- 2.46;分娩后3个月：22.7 +/- 2.55 ng/ mL）;特别是，分娩后3个月母乳中的平均5-HT浓度显著高于初乳。哺乳前即刻、哺乳后1 - 2小时和下一次哺乳事件前即刻，产妇母乳中5-HT的平均浓度分别为23.6 +/- 1.48、22.82 +/- 1.65和21.84 +/- 1.31 ng/mL;经产妇女的平均5-HT浓度分别为25.4 +/- 1.65、23.6 +/- 2.20或22.4 +/- 2.09 ng/mL。有5-HT浓度在每个时间点之间的groups.Conclusion：这个信息可能是有用的，在确定母乳中的5-HT对婴儿的发育和生长的作用没有显着差异。(C)2020爱思唯尔公司All rights reserved.
Objectives: Serotonin (5-hydroxytryptamine; 5-HT) plays an important role in milk volume homeostasis in the mammary glands during lactation, and 5-HT in milk also may affect infant development. The aim of this study was to investigate changes in 5-HT concentration in breast milk according to the duration of lactation and evaluate whether the 5-HT concentration varied before and after nursing.Methods: Healthy nursing Japanese women who had a natural delivery or underwent a cesarean delivery at Iwate Medical University Hospital were included in this study.Results: The mean 5-HT concentration in milk was obtained from multiparous mothers 6 to 7 d after delivery (colostrum) and was significantly higher compared with primiparous mothers (24.3 +/- 2.63 versus 18.5 +/- 2.60 ng/mL). Additionally, mean 5-HT concentration increased with increasing lactation duration in primiparous women (colostrum: 18.5 +/- 2.60; 1 mo postdelivery: 19.8 +/- 2.46; 3 mo postdelivery: 22.7 +/- 2.55 ng/ mL); in particular, the mean 5-HT concentration in breast milk 3 mo after delivery was significantly higher than in colostrum. The mean 5-HT concentrations in breast milk in primiparous mothers immediately before nursing, 1 to 2 h after nursing, and immediately before the next nursing event were 23.6 +/- 1.48, 22.82 +/- 1.65, and 21.84 +/- 1.31 ng/mL, respectively; mean 5-HT concentrations in multiparous women were 25.4 +/- 1.65, 23.6 +/- 2.20, or 22.4 +/- 2.09 ng/mL, respectively. There was no significant difference in 5-HT concentrations at each time point between the groups.Conclusion: This information may be useful in determining the role of 5-HT in breast milk on infant development and growth. (C) 2020 Elsevier Inc. All rights reserved.