Ag/Cu-mediated decarboxylative cyanation of aryl carboxylic acids with K4Fe(CN)(6) under aerobic conditions
Ag/Cu-mediated decarboxylative cyanation of aryl carboxylic acids with K4Fe(CN)(6) under aerobic conditions
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有氧条件下 Ag/Cu 介导的 K4Fe(CN)(6) 芳基羧酸脱羧氰化
DOI：
10.1080/00397911.2018.1494840
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发表时间：
2019
影响因子：
2.1
通讯作者：
Cai Hu
中科院分区：
文献类型：
--
作者：
Fu Zhengjiang;Jiang Ligao;Li Zhaojie;Jiang Yongqing;Cai Hu
在有氧条件下，以Ag/Cu为催化剂，K4 Fe（CN）6为催化剂，苯甲酸为原料，通过脱羧氰化反应合成了芳基腈。使用容易获得的芳基羧酸和绿色K4 Fe（CN）6作为起始原料的方法为先前的氰化方案提供了可行的替代方案。控制实验揭示了铜的过程中的关键作用，并排除了自由基机制的转变的可能性。
A method for facile synthesis of aryl nitriles has been well established via Ag/Cu-mediated decarboxylative cyanation of benzoic acids with K4Fe(CN)6under aerobic conditions. The approach of using readily accessible aryl carboxylic acids and green K4Fe(CN)6as starting material provides a feasible alternative to previous cyanation protocols. Control experiments revealed the key role of Cu for the process and excluded the possibility of a radical mechanism for the transformation.