The Challenge of Predicting Response to Stabilising Lithium Treatment
The Challenge of Predicting Response to Stabilising Lithium Treatment
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预测稳定锂治疗反应的挑战
DOI：
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发表时间：
1993
影响因子：
10.5
通讯作者：
P. Cameron
中科院分区：
文献类型：
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作者：
P. Grof;M. Alda;E. Grof;D. Fox;P. Cameron
锂治疗是一种有充分证据证明有效的方法，最近已经失去了治疗价值。然而，锂继续对那些被证明有效的患者起作用，也就是说，大多数患有原发性发作性情感障碍的患者。这样的锂预防响应者可以通过全面的临床评估预先可靠地识别出来。锂失去疗效的悖论的解释主要在于教育上对全面的患者评估存在偏见，以及诊断方式的转变有利于临床医生心目中的情感障碍和与之相关的治疗方法。
Lithium treatment, an approach with well documented efficacy, has recently been losing its treatment value. Lithium continues working, however, for those patients for whom it was proven efficacious; that is, most patients with primary episodic affective disorders. Such responders to lithium prophylaxis can be reliably identified beforehand by a comprehensive clinical assessment. The explanation for the paradox of lithium's lost efficacy lies mostly in the educational bias against a comprehensive patient assessment, and in the shift in diagnostic fashion favouring affective disorders and the treatment methods associated with them in the clinicians' minds.
DOI：
10.1176/ajp.149.5.638
发表时间：
1992
期刊：
The American journal of psychiatry
影响因子：
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作者：
Stoll,AL;Tohen,M;Baldessarini,RJ
通讯作者：
Baldessarini,RJ