The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility
The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility
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DOI：
10.4012/dmj.2012-117
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发表时间：
2012-11-01
影响因子：
2.5
通讯作者：
Matsuura, Nariaki
中科院分区：
文献类型：
--
作者：
Hamada, Yoshinosuke;Fujitani, Wataru;Matsuura, Nariaki
在组织工程中，具有高生物相容性和高强度的生物可降解高分子材料是长期使用的重要支架材料。因此，在本研究中，我们尝试制备三种类型的聚l -乳酸(PLLA)/磷酸钙（CP）杂化复合材料作为支架生物材料。研究了添加不同CP对其生物相容性和力学性能的影响。CP粉末和孔洞在固体和多孔复合材料中均呈三维均匀分布。CP和PLLA的组合大大提高了细胞粘附性，随着CP在复合材料中体积分数的增加，细胞粘附性增强。对于多孔样品，细胞迁移到孔隙中。本研究表明PLLA和CP复合材料是一种有效的新型支架材料，具有较好的骨导电性、骨再生和矿化性能，并具有中等高的强度。
In tissue engineering, biodegradable polymer materials with both high biocompatibility and high strength are very important as scaffolds for long term use. Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a scaffold biomaterial. The effects of addition of different CP on both biocompatibility and mechanical properties were evaluated. CP powders and voids were three-dimensionally and uniformly distributed in the solid samples and porous composite samples. These compositions of CP and PLLA greatly improved the cellular adhesiveness, which increased as the volume fraction of CP in the composite increased. For the porous samples, cells migrated into the pores. This study demonstrated that a composite of PLLA and CP is an effective new scaffold material that results in better osteoconductivity, bone regeneration, and mineralization and has moderately high strength.