Effect of granulocyte colony-stimulating factor treatment at a low dose but for a long duration in patients with coronary heart disease - A pilot study
Effect of granulocyte colony-stimulating factor treatment at a low dose but for a long duration in patients with coronary heart disease - A pilot study
复制标题
DOI：
10.1253/circj.70.430
复制
发表时间：
2006-04-01
影响因子：
3.3
通讯作者：
Fujiwara, H
中科院分区：
文献类型：
--
作者：
Suzuki, K;Nagashima, K;Fujiwara, H
在动物模型中，粒细胞集落刺激因子（G-CSF）可改善梗死后心功能。然而，在涉及心绞痛和急性心肌梗死（AMI）患者的初步研究中，高剂量的G-CSF经常诱导冠状动脉闭塞或再狭窄，但低剂量的G-CSF没有显示出显著的有益作用。我们假设，低剂量，但持续时间长的G-CSF将有一个有益的效果，而没有严重的并发症，冠心病patients with coronary heartdisease.Methods和结果46例心绞痛或AMI患者随机分为G-CSF和非G-CSF对照组，分别。皮下注射重组G-CSF，每天一次，持续10天。外周血中的白细胞计数控制在约30，000/μ l。一个月后，铊-201单光子发射计算机断层扫描显示G-CSF心绞痛组摄取百分比增加，范围和严重程度评分降低。在G-CSF AMI组，射血分数与肌酸激酶峰值之间的曲线显著上移，与非G-CSF AMI组相比。在6个月的观察期间，没有观察到严重并发症。结论低剂量，但持续时间长的G-CSF治疗冠心病患者可能有有益的效果，没有任何严重并发症。
Background In animal models, granulocyte colony-stimulating factor (G-CSF) improves post-infarct cardiac function. However, in pilot studies involving patients with angina and acute myocardial infarction (AMI), G-CSF at a high dose frequently induced coronary occlusion or restenosis, but those at a low dose showed no significant beneficial effect. We hypothesized that a low dose but long duration of G-CSF will have a beneficial effect without serious complications to patients with coronary heart disease.Methods and Results Forty-six patients with angina or AMI were randomly assigned into G-CSF and non-G-CSF control groups, respectively. Recombinant G-CSF was subcutaneously injected once a day for 10 days. The leukocyte counts in the peripheral blood were controlled at approximately 30,000/mu l. One month later, a Thallium-201 single photon emission computed tomography revealed the increased percentage uptake and the reduced extent and severity scores in the G-CSF angina group. In the G-CSF AMI group, the curve between the ejection fraction and peak creatine kinase shifted significantly upward, compared with that of the non-G-CSF AMI group. Serious complications were not observed during the 6 months of observation.Conclusions A low dose but long duration of G-CSF treatment may have a beneficial effect without any serious complications in patients with coronary heart disease.