Estimation of high-resolution HLA-A, -B, -C,-DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning
Estimation of high-resolution HLA-A, -B, -C,-DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning
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DOI：
10.1016/j.humimm.2009.08.006
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发表时间：
2009-11-01
期刊：
影响因子：
2.7
通讯作者：
Rutt, Claudia
中科院分区：
文献类型：
--
作者：
Schmidt, Alexander H.;Baier, Daniel;Rutt, Claudia
人类白细胞抗原（HLA）在特定人群中的单倍型频率分布可用于优化个体干细胞供体搜索和供体登记计划。我们目前的等位基因和单倍型频率来自一个数据集的8862德国干细胞捐赠者谁是分型在高分辨率的HLA-A，HLA-B，HLA-C，和HLA-DRB 1基因注册。计算的单倍型频率用于估计找到符合供体登记大小n的匹配供体的概率p。分析了不同匹配标准对p（n）的影响。当需要HLA-A、HLA-B、HLA-C和HLA-DRB 1的高分辨率匹配时，p（1，000，000）为0.678。n = 7，000，000的相应值为0.859。在具有低分辨率匹配且不考虑HLA-C的场景中，p（1，000，000）为0.863，因此大于具有更严格匹配要求的场景中的p（7，000，000）。由于最近的研究结果支持HLA-A，HLA-B，HLA-C和HLA-DRB 1的高分辨率匹配对造血干细胞移植结局的重要性，我们的研究结果与供体中心和登记中心的战略规划和资源分配高度相关。(C)2009年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版All rights reserved.
Human leukocyte antigen (HLA) haplotype frequency distributions in specific Populations can be applied to optimize both individual stem cell donor searches and donor registry planning. We present allele and haplotype frequencies derived from a data set of 8862 German stem cell donors who were typed at high resolution for the HLA-A, HLA-B, HLA-C, and HLA-DRB1 genes upon registration. Calculated haplotype frequencies were used to estimate the probability p to find matching donors subject to donor registry size n. The impact of various matching standards on p(n) was analyzed. When high-resolution matching for HLA-A, HLA-B, HLA-C, and HLA-DRB1 is required, p(1,000,000) is 0.678. The corresponding value for n = 7,000,000 is 0.859. In a scenario with low-resolution matching and no consideration of HLA-C, p(1,000,000) is 0.863 and thus larger than p(7,000,000) in the scenario with stricter matching requirements. As recent findings support the importance of high-resolution matching of HLA-A, HLA-B, HLA-C, and HLA-DRB1 for Outcomes of hematopoietic stem cell transplantation, Our results are highly relevant for strategic planning and resource allocation of donor centers and registries. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.