Natural Killer Cell Memory.
Natural Killer Cell Memory.
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DOI：
10.1016/j.immuni.2015.09.013
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发表时间：
2015-10-20
期刊：
影响因子：
32.4
通讯作者：
Lanier LL
中科院分区：
文献类型：
--
作者：
O'Sullivan TE;Sun JC;Lanier LL
自然杀伤（NK）细胞历来被认为是短命的溶细胞细胞，能够以不依赖于抗原的方式快速对病原体和肿瘤做出反应，然后发生细胞死亡。然而，最近NK细胞被证明具有适应性免疫的特性，并且可以以与T细胞和B细胞类似的方式获得免疫记忆。在这篇综述中，我们讨论了 NK 细胞记忆的证据以及这些先天淋巴细胞的生成和存活所涉及的机制。
Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner, and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity, and can acquire immunological memory in a similar manner to T and B cells. In this review, we discuss evidence for NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes.