Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity.
Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity.
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DOI：
10.1017/s0954579417001286
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发表时间：
2017-12
影响因子：
3.3
通讯作者：
Tyrka AR
中科院分区：
文献类型：
--
作者：
Parade SH;Parent J;Rabemananjara K;Seifer R;Marsit CJ;Yang BZ;Zhang H;Tyrka AR
FK506结合蛋白51（FKBP5）改变应激反应系统功能，儿童期虐待与FKBP5基因甲基化有关。然而，目前尚不清楚虐待是否会导致FKBP5甲基化随时间的变化。目前的研究利用了231名学龄前儿童的样本，其中包括123名在过去6个月内有中度至重度虐待的儿童福利文件，以了解虐待是否有助于在6个月内改变FKBP 5甲基化。审查儿童保护记录和半结构化的访谈，在家里被用来评估虐待和暴露于其他背景的压力，以及服务的利用。在初始研究入组时和入组后6个月，从唾液DNA中测量内含子7中两个CpG位点处的FKBP5甲基化。儿童虐待与FKBP 5甲基化随时间的变化有关，但仅当儿童暴露于高水平的其他背景压力源时。随着时间的推移，服务利用与甲基化的增加相关，但仅在具有FKBP5 rs1360780保护性CC基因型的儿童中。FKBP5的甲基化对应激暴露敏感，可能是将早期逆境与长期健康和发育结果联系起来的机制。
FK506 binding protein 51 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate-severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semi-structured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization. Methylation of FKBP5 at two CpG sites in intron 7 was measured from saliva DNA at the time of initial study enrollment, and 6 months following enrollment. Child maltreatment was associated with change in FKBP5 methylation over time, but only when children were exposed to high levels of other contextual stressors. Service utilization was associated with increases in methylation over time, but only among children with the FKBP5 rs1360780 protective CC genotype. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long term health and developmental outcomes.