Psoriasis and Skin Pain: Instrumental and Biological Evaluations
Psoriasis and Skin Pain: Instrumental and Biological Evaluations
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DOI：
10.2340/00015555-1965
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发表时间：
2015-01-01
影响因子：
3.6
通讯作者：
Balato, Anna
中科院分区：
文献类型：
--
作者：
Patruno, Cataldo;Napolitano, Maddalena;Balato, Anna
银屑病患者皮肤疼痛的发病率和疼痛的分子机制尚不清楚。本研究评估了163例斑块状银屑病患者（98例男性，65例女性，年龄范围18-81岁）的皮肤疼痛，评价：与疾病的临床严重程度相比，该症状的主观/客观特征;以及白细胞介素（IL）-33（参与银屑病和疼痛发病机制）在银屑病相关疼痛中的作用。使用的临床测量方法包括调查问卷、斑块医生全球评估（PGA）指数、测量痛阈的压力测痛法和触觉/热敏感性测试。IL-33基因表达在体内（n=12）在患者皮肤和通过离体模型的伤害性感受使用十二烷基硫酸钠。在银屑病患者中，43.6%的患者在前一周报告皮肤疼痛;瘙痒、不适、疼痛、敏感、发热/烧灼感、触痛和痉挛是报告最多的性质。患者痛阈随PGA指数和疼痛强度的增加而降低。与未受影响的银屑病皮肤相比，皮损皮肤对触摸/热的敏感性降低。IL-33的表达在报告疼痛的患者的病变皮肤和离体系统中增加。因此，牛皮癣的治疗方法有哪些？
The prevalence of skin pain and the molecular mechanisms responsible for pain in psoriasis remain unclear. This study assessed skin pain in 163 patients (98 males, 65 females, range 18-81 years) with plaque psoriasis, evaluating: the subjective/objective features of this symptom compared with clinical severity of the disease; and the role of interleukin (IL)-33, (involved in both psoriasis and pain pathogenesis), in psoriasis-related pain. Clinical measures used were a questionnaire, plaque Physician Global Assessment (PGA) index, pressure algometry to measure pain threshold and tactile/thermal sensitivity test. IL-33 gene expression was examined in vivo (n=12) in patients skin and through an ex vivo model of nociception using sodium dodecyl sulphate. Of the psoriatic patients 43.6% reported skin pain during the previous week; itchy, unpleasant, aching, sensitive, hot/burning, tender and cramping were the most reported qualities. Patients' pain threshold decreased with increasing PGA index and pain intensity. Sensitivity to touch/heat was reduced in lesional skin, compared with unaffected psoriatic skin. IL-33 expression was increased in lesional skin of patients reporting pain and in the ex vivo system. In conclusion, symptoms of skin pain should be taken into account in the management of psoriasis.