Quantification of inflammatory bowel disease activity using technetium-99m HMPAO labelled leucocyte single photon emission computerised tomography (SPECT).
Quantification of inflammatory bowel disease activity using technetium-99m HMPAO labelled leucocyte single photon emission computerised tomography (SPECT).
复制标题
使用 Technetium-99m HMPAO 标记的白细胞单光子发射计算机断层扫描 (SPECT) 对炎症性肠病活动进行定量。
作者：
M. Weldon;A M Masoomi;A J Britten;J. Gane;C J Finlayson;A. Joseph;J. D. Maxwell
应用单光子发射计算机断层扫描（SPECT）技术，对23例可疑结肠炎患者进行了~（99）Tc-HMPAO标记白色细胞肠摄取定量研究。在横断图像上定量结肠段的摄取，并表示为骨髓摄取的分数（SPECT评分）。在结肠镜检查（20）或手术（3）时评估节段性组织学疾病活动。节段性组织学评分与SPECT评分相关r = 0.79（p < 0.001）。所有受累节段的总体SPECT评分与克罗恩病活动指数（CDAI）r = 0.66，p = 0.001和实验室活动指数相关;红细胞沉降率r = 0.44，p = 0.03，C反应蛋白r = 0.38，p = 0.05，白蛋白r =-0.46，p = 0.03。13例小肠SPECT评分与CDAI相关r = 0.65，p < 0.01，与血沉、C反应蛋白无相关性。5例小肠白色细胞摄取阳性患者C反应蛋白和血沉均正常。所有部位疾病的SPECT总体评分与CDAI和实验室炎症指数相关。99 mTc HMPAO SPECT提供了无创和准确的定量炎症性肠病活动在大肠和小肠，并可能是有用的炎症性肠病治疗的客观评价。
Technetium-99m HMPAO labelled white cell bowel uptake was quantified in 23 patients with suspected colitis by means of the novel technique of single photon emission computerised tomography (SPECT) using a standard gamma-camera. Uptake in colon segments was quantified on transaxial images and expressed as a fraction of marrow uptake (SPECT score). Segmental histological disease activity was assessed at colonoscopy (20) or at surgery (3). Segmental histology score correlated with SPECT score r = 0.79 (p < 0.001). Overall SPECT score for all affected segments correlated with Crohn's disease activity index (CDAI) r = 0.66, p = 0.001 and with laboratory activity indices; erythrocyte sedimentation rate r = 0.44, p = 0.03, C reactive protein r = 0.38, p = 0.05, and albumin r = -0.46, p = 0.03. Small bowel SPECT score in 13 patients correlated with CDAI r = 0.65, p < 0.01 but not with erythrocyte sedimentation rate or C reactive protein. Five patients with positive small bowel white cell uptake had normal C reactive protein and erythrocyte sedimentation rate. Overall SPECT score for disease at all sites correlated with both CDAI and with laboratory indices of inflammation. 99mTc HMPAO SPECT provides non-invasive and accurate quantification of inflammatory bowel disease activity in both large and small bowel and may be useful in the objective evaluation of treatment for inflammatory bowel disease.