Heart specific expression of mouse BMP-10 a novel member of the TGF-β superfamily
Heart specific expression of mouse BMP-10 a novel member of the TGF-β superfamily
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DOI：
10.1016/s0925-4773(98)00221-4
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发表时间：
1999-02-01
影响因子：
2.6
通讯作者：
Thies, RS
中科院分区：
文献类型：
--
作者：
Neuhaus, H;Rosen, V;Thies, RS
在这里，我们报道了小鼠BMP-10的克隆和表达，这是tgf - β超家族的一个新成员。在小鼠胚胎中，BMP-10的表达始于9.0 d.p.c.，并且仅限于发育中的心脏。最初，BMP-10的表达局限于共同心室小梁部分和心球区。12.5 d.p.c后，心房壁可见额外的BMP-10表达。本研究的数据表明，BMP-10在胚胎心脏的小梁形成中起重要作用。1999爱思唯尔科学爱尔兰有限公司版权所有。
Here we report the cloning and expression of murine BMP-10, a novel member of the TGF-beta superfamily. In the mouse embryo, BMP-10 expression begins at 9.0 d.p.c. and is restricted to the developing heart. Initially, BMP-10 expression localizes to the trabeculated part of the common ventricular chamber and to the bulbus cordis region. After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.