Dynamic changes in the microcirculation of diabetics as related to diabetic microangiopathy.
Dynamic changes in the microcirculation of diabetics as related to diabetic microangiopathy.
复制标题
糖尿病患者微循环的动态变化与糖尿病微血管病变有关。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
E. M. Kohner
中科院分区：
文献类型：
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作者：
E. M. Kohner
在糖尿病微血管病的不可逆结构变化变得明显之前，在早期糖尿病中已经观察到许多血管床的可逆性异常。在球结膜和肾脏中，这些变化与血管功能障碍有关，并且可能是由于自主神经病变所致。自我调节在这些血管床中的作用尚不清楚。在早期糖尿病和仅有轻度视网膜病变的患者中，四肢肌肉和视网膜的功能异常是血流量增加。血流量的增加可能是由于 2,3 二磷酸甘油酸缺乏引起的缺氧的自我调节适应的结果。乳酸积累也可能有所贡献。视网膜自动调节的破坏导致糖尿病性视网膜病变的发生。视网膜病变的晚期阶段，即新血管形成，是对毛细血管无灌注区域进行血运重建的尝试。
Reversible abnormalities of many vascular beds have been observed in early diabetes, before irreversible structural changes of diabetic microangiopathy became apparent. In the bulbar conjenctiva and in the kidney the changes are associated with vascular dysfunction and may be due to autonomic neuropathy. The role of autoregulation in these vascular beds is not clear. In the limb muscles and in the retina the functional abnormality in early diabetes and in those with only mild retinopathy is increased blood flow. This increase in blood flow is probably the result of autoregulatory adaptation to hypoxia induced by 2,3 diphosphoglycerate deficiency. Lactic acid accumulation may also contribute. Breakdown of the autoregulation in the retina results in the development of diabetic retinopathy. The late stages of retinopathy, new vessel formation, are an attempt at revascularisation of areas of capillary non-perfusion.
血流量的测量。
影响因子：
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作者：
BermanJr,W;ListerJr,G;Pitt,BR;Hoffman,JI
通讯作者：
Hoffman,JI