Migraine and risk of cardiovascular disease in men
Migraine and risk of cardiovascular disease in men
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DOI：
10.1001/archinte.167.8.795
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发表时间：
2007-04-23
影响因子：
--
通讯作者：
Buring, Julie E.
中科院分区：
文献类型：
--
作者：
Kurth, Tobias;Gaziano, J. Michael;Buring, Julie E.
背景：偏头痛特异性生理特征的血管成分和观察到的偏头痛患者不良心血管风险特征表明偏头痛与心血管疾病（CVD）之间存在关联。在女性中，偏头痛与心血管疾病（包括冠状动脉事件）的风险增加有关。缺乏男性的相关数据。方法：前瞻性队列研究2084名40 - 84岁男性参加医师健康研究。在年度调查问卷中，男性被问及偏头痛、危险因素和研究终点的发生情况。如果男性在前5年内出现偏头痛，我们将其归类为偏头痛，之后开始随访。没有关于aura的信息。所有的男性在随访开始时都没有心血管疾病。在平均15.7年的时间里，我们对参与者进行了首次主要CVD事件（非致死性缺血性卒中、非致死性心肌梗死或缺血性CVD死亡）的随访。我们还评估了个体终点、冠状动脉血运重建术和心绞痛。结果：共有1449名男性（7.2%）报告偏头痛，在随访期间，发生了2236起主要心血管疾病事件。与非偏头痛患者相比，报告偏头痛的男性主要心血管疾病的多变量调整风险比（95%可信区间）为1.24 (1.06-1.46；P= 0.008)，缺血性中风的多变量调整风险比为1.12 (0.84-1.50；P= 0.43)，缺血性中风的多变量调整风险比为1.42 （1.15-1.77；P= 0.008）
Background: The vascular component of the migraine-specific physiologic profile and the observed adverse cardiovascular risk profile in migraineurs suggest an association between migraine and cardiovascular disease (CVD). In women, migraine has been associated with increased risk of CVD, including coronary events. Compatible data in men are lacking.Methods: Prospective cohort study of 20 084 men aged 40 to 84 years participating in the Physicians' Health Study. In yearly questionnaires, men were asked for information on migraine, risk factors, and the occurrence of study end points. We classified men as having migraine if they indicated migraine during the first 5 years, after which time follow-up began. Information on aura was not available. All the men were free of CVD at the start of follow-up. During a mean of 15.7 years, we followed up participants for the occurrence of a first major CVD event (nonfatal ischemic stroke, nonfatal myocardial infarction, or death from ischemic CVD). We also evaluated the individual end points, coronary revascularization, and angina.Results: A total of 1449 men (7.2%) reported migraine, and during follow-up, 2236 major CVD events occurred. Compared with nonmigraineurs, men who reported migraine had multivariable-adjusted hazard ratios (95% confidence intervals) of 1.24 (1.06-1.46; P=.008) for major CVD, 1.12 (0.84-1.50; P=.43) for ischemic stroke, 1.42 (1.15-1.77; P