Dietary flavonoid intake and non-Hodgkin lymphoma risk
Dietary flavonoid intake and non-Hodgkin lymphoma risk
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DOI：
10.1093/ajcn/87.5.1439
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发表时间：
2008-05-01
影响因子：
7.1
通讯作者：
Ward, Mary H.
中科院分区：
文献类型：
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作者：
Frankenfeld, Cara L.;Cerhan, James R.;Ward, Mary H.
背景：饮食因素在非霍奇金淋巴瘤(NHL)风险中的作用尚不清楚。膳食类黄酮是一种多酚类化合物，被认为具有抗癌作用。黄酮类化合物是具有良好特性的抗氧化剂和金属螯合剂，某些黄酮类化合物表现出抗增殖和抗雌激素作用。目的：我们旨在评估类黄酮类化合物摄入量较高与较低非霍奇金淋巴瘤风险相关的假设。设计：1998-2000年间，我们从4个美国监测、流行病学和最终结果癌症登记中确定了20-74岁的非霍奇金淋巴瘤病例。没有非霍奇金淋巴瘤病史的对照组通过随机数字拨号或从医疗保险文件中选择，并按年龄、中心、种族和性别与病例频率匹配。使用美国农业部最近开发的3个营养特定数据库，根据参与者对117项食物频率问卷(n=466例和390例对照)的回答来估计类黄酮类的摄入量。在调整了年龄、性别、注册登记、教育程度、非霍奇金淋巴瘤家族史和能量摄入后，评估了与四分位数中类黄酮摄入量有关的非霍奇金淋巴瘤风险。结果：总类黄酮类摄入量较高与非霍奇金淋巴瘤的风险显著相关(趋势P<0.01)：摄入量最高四分之一的风险比摄入量最低的低47%(95%可信区间：31%，73%)。摄入较高的黄酮醇、表儿茶素、花青素和原花青素均与降低非霍奇金淋巴瘤的风险显著相关。主要的NHL亚型-弥漫性大B细胞淋巴瘤(n=167)和滤泡性淋巴瘤(n=146)的风险模式也相似。结论：较高的类黄酮摄入量可能与较低的NHL风险有关。
Background: The role of dietary factors in non-Hodgkin lymphoma (NHL) risk is not yet well understood. Dietary flavonoids are polyphenolic compounds proposed to be anticarcinogenic. Flavonoids are well-characterized antioxidants and metal chelators, and certain flavonoids exhibit antiproliferative and antiestrogenic effects.Objective: We aimed to evaluate the hypothesis that higher flavonoid intake is associated with lower NHL risk.Design: During 1998-2000, we identified incident NHL cases aged 20-74 y from 4 US Surveillance, Epidemiology, and End Results cancer registries. Controls without history of NHL were selected by random-digit dialing or from Medicare files and frequency-matched to cases by age, center, race, and sex. Using 3 recently developed US Department of Agriculture nutrient-specific databases, flavonoid intake was estimated from participant responses to a 117-item food-frequency questionnaire (n = 466 cases and 390 controls). NHL risk in relation to flavonoid intake in quartiles was evaluated after adjustment for age, sex, registry, education, NHL family history, and energy intake.Results: Higher total flavonoid intake was significantly associated with lower risk of NHL (P for trend < 0.01): a 47% lower risk in the highest quartile of intake than in the lowest (95% CI: 31%, 73%). Higher intakes of flavonols, epicatechins, anthocyanidins, and proanthocyanidins were each significantly associated with decreased NHL risk. Similar patterns of risk were observed for the major NHL subtypes-diffuse large B-cell lymphoma (n = 167) and follicular lymphoma (n = 146).Conclusion: A higher intake of flavonoids, dietary components with several putative anticarcinogenic activities, may be associated with lower NHL risk.