LABEL-RETAINING CELLS RESIDE IN THE BULGE AREA OF PILOSEBACEOUS UNIT - IMPLICATIONS FOR FOLLICULAR STEM-CELLS, HAIR CYCLE, AND SKIN CARCINOGENESIS
LABEL-RETAINING CELLS RESIDE IN THE BULGE AREA OF PILOSEBACEOUS UNIT - IMPLICATIONS FOR FOLLICULAR STEM-CELLS, HAIR CYCLE, AND SKIN CARCINOGENESIS
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DOI：
10.1016/0092-8674(90)90696-c
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发表时间：
1990-06-29
期刊：
影响因子：
64.5
通讯作者：
LAVKER, RM
中科院分区：
文献类型：
--
作者：
COTSARELIS, G;SUN, TT;LAVKER, RM
与毛囊干细胞位于毛球的基质区域这一观点不同，我们发现标记滞留细胞仅存在于小鼠毛囊的隆突区域。隆突由位于毛囊中部、立毛肌附着部位的外根鞘细胞亚群组成。隆突区域的角质形成细胞在超微结构上相对未分化。它们通常处于缓慢循环状态，但可被佛波醇 -12 - 十四酸 -13 - 乙酸酯（TPA）刺激而短暂增殖。这些细胞位于一个受到良好保护和滋养的环境中，标志着毛囊“永久”部分的下端。我们的研究结果，加上对文献的重新评估，表明毛囊干细胞位于隆突区域，而非毛球下部。这一新观点为毛发周期调控以及毛囊干细胞在皮肤癌变过程中可能的参与作用提供了新的见解。
Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of subpopulation of outer root sheath cells located in the midportion of the follicle at the arrector pill muscle attachment site. Keratinocytes in the bulge area are relatively undifferentiated ultrastructurally. They are normally slow cycling, but can be stimulated to proliferate transiently by TPA. Located in a well-protected and nourished environment, these cells mark the lower end of the "permanent" portion of the follicle. Our findings, plus a reevaluation of the literature, suggest that follicular stem cells reside in the bulge region, instead of the lower bulb. This new view provides insights into hair cycle control and the possible involvement of hair follicle stem cells in skin carcinogenesis.