Update on pertussis and pertussis immunization.
Update on pertussis and pertussis immunization.
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DOI：
10.3345/kjp.2010.53.5.629
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发表时间：
2010-05-01
影响因子：
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通讯作者：
Hong, Jung Yun
中科院分区：
文献类型：
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作者：
Hong, Jung Yun
百日咳是一种由百日咳杆菌感染引起的高度接触性呼吸道疾病。这种感染的临床表现可能严重到足以导致死亡。虽然自开始对儿童广泛接种百日咳疫苗以来，百日咳一直被认为是一种疫苗可预防的疾病，但自1990年代以来，百日咳病例和相关死亡人数呈上升趋势，特别是在疫苗接种覆盖率高的国家。在韩国，自1990年以来没有因百日咳而死亡的病例，疫苗接种率继续保持在94%左右。然而，在2000年代，向韩国疾病控制和预防中心报告的百日咳病例数量有增加的趋势，2009年，报告的百日咳病例数量明显增加。本文就百日咳的发病机制、诊断、治疗和预防作一综述。
Pertussis is a highly contagious respiratory tract disease caused by Bordetella pertussis infection. The clinical manifestation of this infection can be severe enough to cause death. Although pertussis has been supposed to be a vaccine-preventable disease ever since the widespread vaccination of children against pertussis was started, since the 1990s, cases of pertussis and related fatalities are on the rise, especially in countries with high vaccination coverage. In Korea, there have been no deaths due to pertussis since 1990, and the vaccination rate continues to be approximately 94%. However, the number of pertussis cases reported to the Korea Center for Disease Control and Prevention has tended to increase in the 2000s, and in 2009, there was an obvious increase in the number of pertussis cases reported. This review aims to present the latest information about the pathogenesis, diagnosis, treatment, and prevention of pertussis.