Correlation between corin, N-terminal pro-atrial natriuretic peptide and neonatal adverse prognostic in hypertensive disorders of pregnancy
Correlation between corin, N-terminal pro-atrial natriuretic peptide and neonatal adverse prognostic in hypertensive disorders of pregnancy
复制标题
Corin、N端心房钠尿肽前体与妊娠期高血压疾病新生儿不良预后的相关性
DOI：
10.1016/j.preghy.2020.11.007
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发表时间：
2021-03-01
影响因子：
2.2
通讯作者：
Song, Wei
中科院分区：
文献类型：
--
作者：
Lin, Yi;Dong, Yu-bing;Song, Wei
简介：心房利尿肽（ANP）通过促进肾脏钠和水分排泄来调节水盐平衡和血压。目标：我们的研究是研究血浆N末端促纳二钠耐药肽（NT-Proanp）（NT-Proanp）（NT-Proanp）（NT-Proanp）和Corin in Preplatention Disorders（HDP）（HDP）。此外，评估了Corin/NT-ProANP与新生儿不良预后之间的关系。方法：招募了77例HDP患者和48位正常妇女作为对照组。收集临床特征和血浆。血浆NT-ProANP和Corin由ELISA测定。记录了胎龄，新生儿体重和Apgar评分。与对照组相比，HDP组进行了统计分析：HDP组的NT-ProANP和Corin显着增加（P <0.05）。患有过早分娩的HDP患者的NT-Proanp和Corin显着升高（P <0.05）。 NT-Proanp和Corin与HDP组的递送时间，新生儿体重和APGAR分数均负相关。多次回归表明，NT-Proanp和Corin是分娩时间，新生儿体重和Apgar得分的独立危险因素。结论：HDP中的血浆NT-ProANP和Corin显着增加。 NT-Proanp和Corin与HDP患者的新生儿不良事件有关。因此，NT-Proanp和Corin可能成为评估HDP患者妊娠严重程度和新生儿不良事件的新生物标志物。
Introduction: Atrial natriuretic peptide (ANP) regulates water-salt balance and blood pressure by promoting renal sodium and water excretion.Objective: Our study was to investigate plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and corin in hypertensive disorders of pregnancy (HDP) patients. Furthermore, the relationship between corin/NT-proANP and neonatal adverse prognosis were evaluated.Methods: Seventy-seven HDP patients and forty-eight normotensive women as control group were recruited. Clinical characteristic and plasma were collected. Plasma NT-proANP and corin were determined by ELISA. Gestational age, neonatal weight and APGAR scores were recorded. Statistical analysis was conducted.Results: NT-proANP and corin were significantly increased in HDP group compared with that of control (P < 0.05). NT-proANP and corin were significantly elevated in HDP patients who suffered from premature delivery (P < 0.05). Both NT-proANP and corin were negatively associated with delivery time, neonatal weight and APGAR scores in HDP group. Multiple regressions demonstrated that NT-proANP and corin were independent risk factor of delivery time, neonatal weight and APGAR scores.Conclusions: Plasma NT-proANP and corin were significantly increased in HDP. NT-proANP and corin were associated with neonatal adverse events in HDP patients. Thus, NT-proANP and corin may become new biomarkers for evaluating severity of pregnancy and neonatal adverse events in HDP patients.