Depression and the risk of Alzheimer disease
Depression and the risk of Alzheimer disease
复制标题
DOI：
10.1097/01.ede.0000152116.32580.24
复制
发表时间：
2005-03-01
期刊：
影响因子：
5.4
通讯作者：
Green, A
中科院分区：
文献类型：
--
作者：
Andersen, K;Lolk, A;Green, A
背景：多项流行病学研究已将抑郁症视为阿尔茨海默病的危险因素，但结果相互矛盾。大多数研究依赖于自我报告的抑郁症，但据报道，自我报告的抑郁症与临床诊断之间的一致性很弱，从而稀释了这种关联。 方法：在丹麦欧登塞对 3346 名年龄 65-84 岁的人进行了队列研究，在基线（1992-1994 年）、2 年（1994-1996 年）和 5 年（1997-1999 年）后进行了检查。在基线时收集抑郁症史作为自我报告。我们使用逻辑回归模型来估计比值比 (OR) 和 95% 置信区间 (CI)。结果：有抑郁症病史的人在基线（OR = 1.7；CI = 1.0-2.7）和随访时（2 年时为 1.9 [1.0-3.3]，5 年时为 1.6 [0.9-2.7]）患阿尔茨海默病的风险均增加。结论：抑郁症是与阿尔茨海默病的风险增加有关。比值比低于后续研究的一般报告，与横断面研究相似。
Background: Several epidemiologic studies have examined depression as a risk factor for Alzheimer disease with conflicting results. Most studies relied on self-reported depression, but the agreement between self-reported depression and clinical diagnosis has been reported to be weak, thereby diluting the association.Methods: A population-based cohort in Odense, Denmark, of 3346 persons age 65-84 years was examined at baseline (1992-1994) and after 2 years (1994-1996) and 5 years (1997-1999). History of depression was collected at baseline as self-report. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs).Results: Persons with a history of depression had an increased risk of Alzheimer disease both at baseline (OR = 1.7; CI = 1.0-2.7) and at follow up (at 2 years, 1.9 [1.0-3.3] and at 5 years, 1.6 [0.9-2.7]).Conclusions: Depression was associated with an increased risk of Alzheimer disease. The odds ratios were lower than generally reported from follow-up studies and are similar to cross-sectional studies.