Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity
Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity
复制标题
DOI：
10.1016/j.virol.2015.05.021
复制
发表时间：
2015-10-01
期刊：
影响因子：
3.7
通讯作者：
Blattman, Joseph N.
中科院分区：
文献类型：
--
作者：
McAfee, Megan S.;Huynh, Trung P.;Blattman, Joseph N.
在了解对病毒感染的免疫力方面取得了很大的进展。然而，感染可能发生在由调节免疫反应和/或疾病的无关病原体共同感染的情况下。我们研究了两种无关病毒：蜕皮病病毒(ECTV)和淋巴细胞性脉络膜脑膜炎病毒(LCMV)合并感染时的免疫力和疾病。ECTV感染对小鼠来说可能是致命的，部分原因是I型干扰素(干扰素-I)的阻断。我们发现ECTV/LCMV混合感染导致ECTV病毒载量降低和ECTV引起的疾病的改善，这可能是由于LCMV诱导的干扰素-I，因为在干扰素-I受体缺陷的小鼠中没有观察到挽救。然而，与单独感染LCMV的小鼠相比，ECTV联合感染的小鼠对LCMV的免疫反应也较低，并可能倾向于产生效应记忆细胞。因此，我们为病毒混合感染调节疾病和免疫的双向效应提供了证据。(C)2015 Elsevier Inc.保留所有权利。
Great progress has been made in understanding immunity to viral infection. However, infection can occur in the context of co-infection by unrelated pathogens that modulate immune responses and/or disease. We have studied immunity and disease during co-infection with two unrelated viruses: Ectromelia virus (ECTV) and Lymphocytic Choriomeningitis virus (LCMV). ECTV infection can be a lethal in mice due in part to the blockade of Type I Interferons (IFN-I). We show that ECTV/LCMV co-infection results in decreased ECTV viral load and amelioration of ECTV-induced disease, likely due to IFN-I induction by LCMV, as rescue is not observed in IFN-I receptor deficient mice. However, immune responses to LCMV in ECTV co-infected mice were also lower compared to mice infected with LCMV alone and potentially biased toward effector-memory cell generation. Thus, we provide evidence for bidirectional effects of viral co-infection that modulate disease and immunity. (C) 2015 Elsevier Inc. All rights reserved.