Abuse during childhood and adolescence and risk of adult-onset asthma in African American women
Abuse during childhood and adolescence and risk of adult-onset asthma in African American women
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DOI：
10.1016/j.jaci.2012.10.023
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发表时间：
2013-04-01
影响因子：
14.2
通讯作者：
Rosenberg, Lynn
中科院分区：
文献类型：
--
作者：
Coogan, Patricia F.;Wise, Lauren A.;Rosenberg, Lynn
背景资料：暴力的经历有助于儿童哮喘的发生，但是关于早期虐待对成人哮喘发作的影响的信息很少。目的：我们前瞻性地评估了黑人妇女健康研究中儿童和青少年时期身体虐待和性虐待与成人哮喘发作的发病率之间的关系。从1995年到2011年，我们对28,456名女性进行了两年一次的邮寄问卷调查。2005年获得了儿童和青少年时期遭受身体虐待和性虐待的经历。考克斯回归模型被用来估计发病率比（IRR）和95%CIs.Results：在417,931人年的后续行动，1,160名参与者报告医生诊断的哮喘和哮喘药物的同时使用。与儿童期或青春期未遭受虐待的女性相比，任何儿童期虐待的多变量IRR为1.24（95% CI，1.06-1.45），任何青春期虐待的多变量IRR为1.10（95% CI，0.88-1.36）。儿童期身体虐待的IRR（IRR，1.29; 95% CI，1.07-1.49）高于儿童期性虐待（IRR，1.15; 95% CI，0.88-1.49）。青春期身体虐待和性虐待的IRR与1.0相容。儿童期虐待和哮喘发病率之间的关联是较强的老年人相比，年轻的women.Conclusion：在这个大队列的非洲裔美国妇女，有一个积极的关联之间的成年发病的哮喘和儿童期的身体虐待和较弱的协会儿童期的性虐待和任何虐待在青春期。鉴于哮喘和儿童虐待的高患病率，这种关联具有公共卫生重要性。（J Allergy Clin Immunol 2013; 131：1058-63.）
Background: Experiences of violence contribute to the occurrence of childhood asthma, but there is little information on the effect of early-life abuse on adult-onset asthma.Objective: We prospectively assessed the relation between physical and sexual abuse during childhood and adolescence and the incidence of adult-onset asthma in the Black Women's Health Study.Methods: We followed 28,456 women from 1995 through 2011 with biennial mailed questionnaires. Experiences of physical and sexual abuse that occurred during childhood and adolescence were obtained in 2005. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% CIs.Results: During 417,931 person-years of follow-up, 1,160 participants reported physician-diagnosed asthma and concurrent use of asthma medication. Compared with women who experienced no abuse during childhood or adolescence, the multivariable IRR for any childhood abuse was 1.24 (95% CI, 1.06-1.45), and for any adolescent abuse, it was 1.10 (95% CI, 0.88-1.36). The IRR was higher for childhood physical abuse (IRR, 1.29; 95% CI, 1.07-1.49) than for childhood sexual abuse (IRR, 1.15; 95% CI, 0.88-1.49). IRRs for physical and sexual abuse during adolescence were compatible with 1.0. The association between childhood abuse and asthma incidence was stronger in older compared with younger women.Conclusion: In this large cohort of African American women, there was a positive association between adult-onset asthma and childhood physical abuse and weaker associations for childhood sexual abuse and any abuse during adolescence. Given the high prevalence of asthma and childhood abuse, this association is of public health importance. (J Allergy Clin Immunol 2013; 131:1058-63.)