Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus
Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus
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DOI：
10.1006/dbio.1996.0148
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发表时间：
1996-07-10
影响因子：
2.7
通讯作者：
Yost, HJ
中科院分区：
文献类型：
--
作者：
Danos, MC;Yost, HJ
左右身体轴与正交的背腹和前后身体轴协调一致。调节轴协调的发育机制尚不清楚。在这里，它表明，心脏左右方向在斑马鱼（Danio rerio）是随机的脊索缺陷无尾和浮动头突变体。无尾（Brachyury）和浮头（Xnot）编码在组织器和脊索中表达的推定转录因子，所述组织器和脊索是调节脊椎动物胚胎的背腹和前后发育的结构。从背部组织摘除和心脏原基rectation的结果表明，心脏的左，右方向是依赖于背前结构，包括脊索和指定在非洲爪蟾的神经褶皱阶段。因此，脊索协调脊椎动物身体平面中所有三个身体轴的发展。(C)出版社：Academic Press，Inc.
The left-right body axis is coordinately aligned with the orthogonal dorsoventral and anterioposterior body axes. The developmental mechanisms that regulate axis coordination are unknown. Here it is shown that the cardiac left-right orientation in zebrafish (Danio rerio) is randomized in notochord-defective no tail and floating head mutants. no tail (Brachyury) and floating head (Xnot) encode putative transcription factors that are expressed in the organizer and notochord, structures which regulate dorsoventral and anterioposterior development in vertebrate embryos. Results from dorsal tissue extirpation and cardiac primordia explantation indicate that cardiac left-right orientation is dependent on dorsoanterior structures including the notochord and is specified during neural fold stages in Xenopus laevis. Thus, the notochord coordinates the development of all three body axes in the vertebrate body plan. (C) 1996 Academic Press, Inc.