The convenient synthesis of hydrogen-bonded ureidopyrimidinones
The convenient synthesis of hydrogen-bonded ureidopyrimidinones
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DOI：
10.1002/ejoc.200300752
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发表时间：
2004-06-14
影响因子：
2.8
通讯作者：
Meijer, EM
中科院分区：
文献类型：
--
作者：
Keizer, HM;Sijbesma, RP;Meijer, EM
封端的异胞嘧啶异氰酸酯通过1，1 ′-羰基二咪唑（CDI）与异胞嘧啶的反应方便地获得。四重氢键结构的所得前体可以被分离和储存以供进一步使用。与脂肪族胺或芳香族胺的反应以良好至优异的分离产率得到相应的单官能、双官能或三官能脲基嘧啶酮衍生物。((C)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2004）。
Blocked isocytosine isocyanates are conveniently obtained by the reaction of 1,1'-carbonyldiimidazole (CDI) with isocytosines. The resulting precursors for quadruple hydrogen-bonded structures can be isolated and stored for further use. Reaction with either aliphatic or aromatic amines gives the corresponding mono-, bi-, or trifunctional ureidopyrimidinone derivatives in good to excellent isolated yields. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).