Predicting Potential Placebo Effect in Drug Treated Subjects
Predicting Potential Placebo Effect in Drug Treated Subjects
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DOI：
10.2202/1557-4679.1152
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发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Govindarajulu, Usha
中科院分区：
文献类型：
--
作者：
Petkova, Eva;Tarpey, Thaddeus;Govindarajulu, Usha
在治疗精神疾病时，对治疗的非特异性反应(通常称为安慰剂反应)普遍存在。用活性药物治疗的受试者可能部分由于治疗的非特异性方面，即那些与药物的化学作用无关的方面而产生反应。为了确定受试者对药物的化学效应的反应程度，必须将特定的药物效应与非特定的安慰剂效应分开。本文提出了一种独特的统计模型，允许对药物治疗受试者的特定效果和非特定效果进行单独预测。一项比较氟西汀和安慰剂治疗抑郁症的临床试验的数据被用来说明这一方法。
Non-specific responses to treatment (commonly known as placebo response) are pervasive when treating mental illness. Subjects treated with an active drug may respond in part due to nonspecific aspects of the treatment, i.e, those not related to the chemical effect of the drug. To determine the extent a subject responds due to the chemical effect of a drug, one must disentangle the specific drug effect from the non-specific placebo effect. This paper presents a unique statistical model that allows for the separate prediction of a specific effect and non-specific effects in drug treated subjects. Data from a clinical trial comparing fluoxetine to a placebo for treating depression is used to illustrate this methodology.