Delirious behavior in influenza is associated with a reversible splenial lesion
Delirious behavior in influenza is associated with a reversible splenial lesion
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DOI：
10.1016/j.braindev.2008.07.013
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发表时间：
2009-06-01
影响因子：
1.7
通讯作者：
Barkovich, A. James
中科院分区：
文献类型：
--
作者：
Takanashi, Jun-ichi;Tada, Hiroko;Barkovich, A. James
谵妄行为是具有可逆性压部病变的临床轻度脑炎/脑病患者的主要临床特征之一。另一方面，据报道，日本有超过10%的流感患者出现神志不清的行为。对患有流感相关谵妄行为的患者进行磁共振成像（MRI）研究，以确定可逆性压部病变与这种症状相关的频率。使用 MRI 和 EEG 对 2007 年 11 月至 2008 年 3 月期间出现与流感相关的神志不清行为到龟田医疗中心就诊的所有患者进行了研究。 370 名流感患者中，有 11 人出现精神错乱，持续时间不到 12 小时。 MRI 显示 5 名患者存在可逆性压部病变，弥散均匀减少。在接受检查的 9 名患者中，有 4 名观察到短暂性脑电图异常（清醒时枕叶慢波）。具有扩散减少的可逆性压部病变应被视为具有与流感相关的谵妄行为的患者的潜在病症。 (C) 2008 Elsevier B.V. 保留所有权利。
Delirious behavior is one of the main clinical features in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion. On the other hand, it has been reported that more than 10% of patients with influenza in Japan develop delirious behavior. Magnetic resonance imaging (MRI) studies in patients with influenza-associated delirious behavior were examined to determine how often a reversible splenial lesion is associated with this symptom. All patients who presented to Kameda Medical Center between November 2007 and March 2008 with delirious behavior associated with influenza were studied using MRI and EEG. Of the 370 patients with influenza, 11 had delirious behavior, lasting for less than 12 h. MRI revealed a reversible splenial lesion with homogenously reduced diffusion in 5 patients. Transient EEG abnormalities (occipital slow waves during wakefulness) were observed in 4 of the 9 patients examined. A reversible splenial lesion with reduced diffusion should be considered as an underlying condition in patients with delirious behavior associated with influenza. (C) 2008 Elsevier B.V. All rights reserved.