Functional inactivation of dorsal hippocampus impairs active place avoidance in rats
Functional inactivation of dorsal hippocampus impairs active place avoidance in rats
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DOI：
10.1016/s0304-3940(00)01019-3
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发表时间：
2000-05-05
影响因子：
2.5
通讯作者：
Bures, J
中科院分区：
文献类型：
--
作者：
Cimadevilla, JM;Fenton, AA;Bures, J
本文评估了海马体对 Long-Evans 大鼠在新地方回避任务中空间定向的贡献。动物们学会在旋转场地的一部分中避免轻微的足部震动。由于惩罚区域是在静止房间的坐标系中定义的，因此即使对象是不动的，也被迫远离禁止部分。双侧背侧海马注射河豚毒素（5ng/1μl生理盐水）后，大鼠无法避开受罚位置，而注射类似的生理盐水也不影响表现。结果表明该任务适合评估实验室啮齿动物的海马依赖性空间能力。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
This paper assesses the contribution of hippocampus to the spatial orientation of Long-Evans rats in a new place avoidance task. The animals learn to avoid a mild footshock in a segment of a rotating arena. Since the punished region is defined in the coordinate system of the stationary room the subject is forced to move away from the prohibited segment even if it is immobile. After bilateral injection of tetrodotoxin (5 ng in 1 mu l of saline) into the dorsal hippocampus rats were not able to avoid the punished place while a similar injection of saline did not affect performance. The results suggest the task is suitable for assessing the hippocampus-dependent spatial abilities of laboratory rodents. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.