A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices.
A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices.
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DOI：
10.1038/nmat4355
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发表时间：
2015-10
期刊：
影响因子：
41.2
通讯作者：
Traverso G
中科院分区：
文献类型：
--
作者：
Zhang S;Bellinger AM;Glettig DL;Barman R;Lee YA;Zhu J;Cleveland C;Montgomery VA;Gu L;Nash LD;Maitland DJ;Langer R;Traverso G
驻留在胃中的设备——用于各种临床应用，包括减肥的营养调节，用于诊断和监测的可摄取电子设备，以及用于延长药物递送的胃保留剂型——通常包含弹性聚合物，在通过食道和消化系统中的其他狭窄孔递送时压缩设备。然而，在意外器械断裂或移动的情况下，这些材料的不可降解性可能会导致肠梗阻。在这里，我们展示了一种弹性的、ph响应的超分子凝胶在胃的酸性环境中保持稳定和弹性，但可以在小肠和大肠的中性ph环境中溶解。在大型动物模型中，以这些材料为关键成分的原型装置显示出延长胃潴留和安全通过。这些肠用弹性体应该会增加各种胃保留装置的安全性。
Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage forms for prolonged drug delivery -- typically incorporate elastic polymers to compress the devices during delivery through the esophagus and other narrow orifices in the digestive system. However, in the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. These enteric elastomers should increase the safety profile for a wide range of gastric retentive devices.