miRNAs in human cancer.
miRNAs in human cancer.
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DOI：
10.1002/path.2806
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发表时间：
2011-01
影响因子：
7.3
通讯作者：
Tuschl, Thomas
中科院分区：
文献类型：
--
作者：
Farazi, Thalia A.;Spitzer, Jessica I.;Morozov, Pavel;Tuschl, Thomas
关键词：
成熟的microrna （mirna）是20- 23个核苷酸（nt）长度的单链RNA分子，在许多细胞过程中控制基因表达。这些分子通常会降低mrna的稳定性，包括那些介导肿瘤发生过程的基因，如炎症、细胞周期调节、应激反应、分化、凋亡和侵袭。miRNA靶向主要是通过miRNA的5 '端（“种子”区）与mrna编码区和非翻译区（utr）内的位点之间的特定碱基配对相互作用来实现的；3 ' UTR中的靶点导致更有效的mRNA不稳定。由于miRNA经常靶向数百种mrna，因此miRNA调控途径非常复杂。为了提供miRNA在癌症中的失调的重要概述，我们首先讨论了目前用于研究miRNA在癌症中的作用的方法，然后回顾了miRNA的基因组组织、生物发生和目标识别机制，研究了这些过程在肿瘤发生中是如何改变的。鉴于mirna在肿瘤发生过程中发挥的关键作用及其疾病特异性表达，它们具有作为治疗靶点和新型生物标志物的潜力。
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20- to 23-nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and invasion. miRNA targeting is mostly achieved through specific base-pairing interactions between the 5′ end (“seed” region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs; target sites in the 3′ UTR lead to more effective mRNA destabilization. Since miRNAs frequently target hundreds of mRNAs, miRNA regulatory pathways are complex. To provide a critical overview of miRNA dysregulation in cancer we first discuss the methods currently available for studying the role of miRNAs in cancer and then review miRNA genomic organization, biogenesis, and mechanism of target recognition examining how these processes are altered in tumorigenesis. Given the critical role miRNAs play in tumorigenesis processes and their disease specific expression, they hold potential as therapeutic targets and novel biomarkers.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
10.5
作者：
Babiarz, Joshua E.;Ruby, J. Graham;Blelloch, Robert
通讯作者：
Blelloch, Robert
DOI：
10.1073/pnas.0404432101
发表时间：
2004-08-10
影响因子：
11.1
作者：
Calin, GA;Liu, CG;Croce, CM
通讯作者：
Croce, CM
影响因子：
4.8
作者：
Berninger, Philipp;Gaidatzis, Dimos;Zavolan, Mihaela
通讯作者：
Zavolan, Mihaela